Twelve healthy male Peruvian students, aged 18-23, who were residing in“low land” (Lima, 150m above sea level) were rapidly taken to“high land”in Peru (Cerro de Pasco, 4, 250m above sea level) by train, stayed there for 5 days and returned to Lima by bus. The change of their plasma levels of testosterone was studied before, during and after sojourn at high altitude.
1. In 11 subjects, excepting one subject who complained heavy symptoms of acute mountain sickness, mean value (±S.D.) of control plasma testosterone level at Lima was 6, 06±1.94ng/m
l; the values during sojourn at altitude were 8.57±3.23, 8, 94±2, 59, 8, 49±2, 53, 7.93±2, 28 and 8.07±2.30ng/m
lon the 1st day to 5th day, respectively; the value immediately after returning to Lima was 7, 07±1.69ng/m
land 6.82±1.69ng/m
lat one week later. The increase from the control value during sojourn at altitude was statistically significant (p<0, 01-0, 05) except the value on the 4th day.
2. The increasing rate of plasma testosterone level during sojourn at altitude was higher in new commers than that in the subjects who had experienced short stay at high altitude above 3, 000m in the past.
3. From these results and available references in which the increased hematopoietic action and erythorcytic 2, 3-DPG level by the administration of testosterone were described, several possibilities were assumed that secretion of androgen, including testosterone, have a close relation with physiological mechanism of acclimatization to high altitude in man.
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