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Volume 24, Issue 3
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1987 Volume 24 Issue 3 Pages 91
Published: December 01, 1987
Released on J-STAGE: October 13, 2010
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Yoshiaki ISOBE, Kokichi OHARA1987 Volume 24 Issue 3 Pages 93-103
Published: December 01, 1987
Released on J-STAGE: October 13, 2010
JOURNAL FREE ACCESSDiurnal variations in the degree of rectal temperature (Tre) fall were examined with rats intraperitoneally given pentobarbital (3 mg/100g B.W.) or capsaicin (0.05mg/100g B.W.) . These drugs were administered to each animal at a specially scheduled time of day under the lighting regimes of light (0700-1900) and dark (1900-0700) . Time-dependent changes in the degree of Tre fall by pentobarbital showed a bimodal pattern and the fall was greater, in animals given drugs, during the dark period than during the light one. Duration of sleep, determined as the interval after injection up to regaining of righting reflex, did not always parallel with the degree of Tre drop. In the case of capsaicin, the decrease in Tre was greater during the dark period than during the light one. These phenomena were accompanied by reciprocal changes of skin temperature (Tsk) increase. Circadian rhythms of basal Tre and Tsk showed the reciprocal relationship. These results indicate that the heat loss system is more important than the heat production one in the generation of body temperature rhythm.View full abstractDownload PDF (1376K) -
Masao FUKUSHIMA, Toshio KOBAYASHI, Keishi KUBO, Kazuhiko YOSHIMURA, To ...1987 Volume 24 Issue 3 Pages 105-110
Published: December 01, 1987
Released on J-STAGE: October 13, 2010
JOURNAL FREE ACCESSThe effects of nonhypoxic decompression on platelet counts and functions were studied by using the decompression chamber at Shinshu University in Matsumoto (660 meter above sea level) . Twenty-five healthy male volunteers, 19 to 25 years old, were exposed to a simulated altitude of 6, 000 m for 2 hours with breathing oxygen. The rate of de- or re- compression was 360 m per minutes. Consequently, the significant decrease in platelet counts (p<0.05), approximately 7 percents lower than those of the preexposure level, was observed after 48 hours of the exposure. Such decrease, however, was not observed during the exposure. The platelet adhesiveness and aggregability increased significantly, p<0.01 and p<0.05, respectively, during the exposure. The concentration of the plasma β-thromboglobulin also increased significantly (p<0.05) during the exposure. These findings indicate that the simulated altitude exposure without hypoxia causes some changes in platelet functions. These changes may be considered to be one of the essential factors in the pathogenesis of acute mountain sickness including high altitude pulmonary edema.View full abstractDownload PDF (802K) -
Masako MOMIYAMA, Masahiro KAGAMI1987 Volume 24 Issue 3 Pages 111-115
Published: December 01, 1987
Released on J-STAGE: October 13, 2010
JOURNAL FREE ACCESSTo clarify the relationship between the cerebrovascular disease mortality and the climatic condition in winter, the regional pattern of the mortality rate in each climate region in winter was examined, assuming that exposure to low temperature in winter is one of the main risk factors of this disease mortality. Furthermore, the seasonal variation of the mortality rates in these regions were also examined respectively. The results obtained are summerized as follow:
1. Comparing the regional variance of the mortality rate in each subregion the highest mortality rate is found in the regions where the mean temperature is about 0°C and the diurnal variance of the temperature is the biggest and ranges about 8-40°C. In particular, in northeastern Japan such climatic condition in winter seems to be related to the risk factors of this disease.
2. The mortality rate tends to increase dramatically in winter in every region, and no significant regional difference can be found in the seasonal variation of the mortality. This study made clear the effect of the physical conditions, in particular the temperature in winter on the regional variance of the cerebrovascular disease mortality in Japan.View full abstractDownload PDF (624K) -
1987 Volume 24 Issue 3 Pages 115c
Published: 1987
Released on J-STAGE: October 13, 2010
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1987 Volume 24 Issue 3 Pages 115d
Published: 1987
Released on J-STAGE: October 13, 2010
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1987 Volume 24 Issue 3 Pages 115b
Published: 1987
Released on J-STAGE: October 13, 2010
JOURNAL FREE ACCESSDownload PDF (57K) -
1987 Volume 24 Issue 3 Pages 115a
Published: 1987
Released on J-STAGE: October 13, 2010
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Takuji KISHIMOTO1987 Volume 24 Issue 3 Pages 117-124
Published: December 01, 1987
Released on J-STAGE: October 13, 2010
JOURNAL FREE ACCESSThe effects of antifebriles, sulpyrine and aspirin, on human vascular endothelial cells at high temperature were investigated. The human vascular endothelial cells were isolated from human umbilical cord veins by collagenase treatment and cultured successively in aerated synthetic medium, RPMI 1640, with 20% precolostrum new born calf serum. The presence of factor VIII antigen in the human vascular endothelial cells was determined by enzyme-labeled antibody method. Normality of the human vascular endothelial cells was characterized on their chromosome pattern. The human vascular endothelial cells were inoculated at the cell density of 5.0×104/ml in dishes and cultured for 24 hours at 37°C. The cells were then inoculated for 3 hours at 37°C or 40°C in Hanks's balanced salt solution with or wtihout each antifebrile. Cell count and protein amount were examined at regular intervals and cell structure was observed by a phase-contrast microscope. The results were summarized as follows : sulpyrine was more toxic to the cultured cells than aspirin at 37°C. The cytotoxicity of sulpyrine was more markedly enhanced at 40°C than at 37°C. However, there was no enhancement in the cytotoxicity of aspirin at 40°C.View full abstractDownload PDF (9211K) -
Takashi KUMAE, Kazuo SUGAWARA, Kazuhiko MACHIDA, Akira SHIMAOKA, Shige ...1987 Volume 24 Issue 3 Pages 125-134
Published: December 01, 1987
Released on J-STAGE: October 13, 2010
JOURNAL FREE ACCESSFor the purpose of investigating changes in effects of seasons on body fluids, the levels of blood water contents and serum electrolytes were examined over a year.
Blood samples from the median cubital vein were collected every month (from May 1983 to February 1984) from a group of healthy adults (13 males) with a mean age of 21.5 years.
1. Blood was always collected at the rising hour (A.M. 6 : 00 from April to November and A.M. 6 : 30 from December to March) in basal metabolic condition.
2. Blood water contents were masured by the lyophilization method and serum electrolytes, Na, K, Ca, Cl, and P were measured by Technicon Auto Analyzer SMAC. The obtained values were individually standardized for each individual subject (a person's value of a month/a corresponding person's mean values of a year) and then were examined for seasonal changes.
3. Blood water content changed significantly. The change of blood water content was unique; drops in the level were found in September and from January to April, and rises were found from June to July and in November. Statistical significances (P<0.001; Student's t-test) were observed between the monthly mean values of July and those of March and September.
4. Serum cationic electroytes, Na, K and Ca changed significantly with a circannual rhythm. Na and K had a opposite rhythm. Statistical significances (P<0.001; Student's t-test) were observed in all cationic electrolytes between the highest monthly mean values and the lowest.
5.Serum anionic electrolytes, Cl and P also changed significantly. Cl and P had a opposite rhythm. Statistical significances (P<0.001; Student's t-test) were observed in all anionic electrolytes between the highest monthly mean values and the lowest.
6. Difference between total serum cationic and total anionic electrolytes changed significantly with a circannual rhythm; a drop in the level was found from September to December and a rise from April to May. Statistical significance (P<0.001; Student's t-test) was revealed between the monthly mean of May and the value of November.View full abstractDownload PDF (1157K) -
—with regard to a transient stageNarihiko KONDO, Takeshi NISHIYASU, Yoshiharu NABEKURA, Haruo IKEGAMI1987 Volume 24 Issue 3 Pages 135-144
Published: December 01, 1987
Released on J-STAGE: October 13, 2010
JOURNAL FREE ACCESSThe purpose of this study is to make a comparison of sweating control between rest and exercise in a transient stage as evidenced by frequency of sweat expulsions. Six healthy males were exposed to a hot environment (45°C, 30% RH) during rest for 2 hours and followed by a light exercise of 180 kpm⋅min-1 (exercise-1) in the same environment. They also performed a moderate exercise of 540 or 720 kpm⋅min-1 (exercise-2) in a mild environment (26°C, 50% RH) . Local sweat rate on the right forearm (msw) was continuously recorded using a capsule method with a capacitance hygrometer. Frequency of sweat expulsions (Fsw) was calculated from another hygrogram. Rectal temperature (Tre), mean skin temperature (Tsk), mean body temperature (Tb), HR and VO2 were determined intermittently through the experiments. The results obtained were as follows :
1. Local sweat rate at a given body temperature (Tre, Tb) was always much higher during exercise than during rest.
2. A highly significant positive correlation was obtained between Tb and Fsw, and between Fsw and msw during a transient stage under three experimental conditions.
3. The regression lines of Tb-Fsw relationship during both exercises were located above that of the rest. Moreover, the slope of the regression line during exercise-1 was steeper than that of the rest but that of exercise-2 showed a tendency to be flatter than that of the rest.
4. The slopes of Fsw-msw relationship during both exercises were steeper than that of the rest, while the regression line of the same relationship during exercise-2 was located above that of the rest.
There results suggest that sweat gland activity and sensitivity for central drive as well as central sudomotor activity is accentuated by exercise, and that sweating control mechanism during exercise is influenced by some different factors as compared with during rest.View full abstractDownload PDF (1385K)
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