There is a growing appreciation of biologically important oligosaccharide units involved in glycoconjugates. As the functions of oligosaccharides in biology became apparent, the efficient synthesis of these substances has become of greater interest. This review describes practical synthesis of di-, tri- and tetrasaccharide units through mainly glycosidase-mediated transglycosylation. A survey of the studied enzymes: β-D-galactosidase,
N-acetylhexosaminidase, α-L-fucosidase, β-D-mannanase and α-D-mannosidase, show them to be very useful for the practical synthesis of biologically important oligosaccharides and their derivatives.
View full abstract