A 6-year-old female Airedale Terrier presented with pigmented alopecia on the nose bridge, the pinnae, and the bilateral flank. Alopecia had been recognized at 1 year of age, and has been seen from February to August every year. Complete blood counts, blood chemistry analyses, TT4, fT4, and C-TSH level did not show any abnormalities. Histopathologic examination of the skin lesion revealed dilation of the follicular infundibula with hyperkeratosis and epidermal hyperpigmentation. Based on these findings, this dog was diagnosed as having recurrent flank alopecia with hair loss on the nose bridge and the pinnae. Her mother and a littermate had been kept by a different owner and had similar clinical findings of recurrent seasonal alopecia on the same areas. To the best of our knowledge, this is the first case of familial onset of the alopecia.

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Two cats with skin fragility syndrome and Intra-abdominal lymphoma were described. Ten-year-old, spayed female domestic shorthaired cat presented with skin tears on the dorsal neck, anorexia, and weight loss. Nodules were detected at the liver, and lymphoma was diagnosed by fine-needle biopsy. Middle aged, female domestic shorthaired cat presented with anorexia. Intra-abdominal nodules were detected, and granule lymphoma was diagnosed by fine-needle biopsy. Then, large area of skin tears appeared over the shoulder. In both cases, histopathological examinations revealed marked epidermal and dermal atrophy. Unfortunately, these cats died. It is suspected that etiological relationships between feline skin fragility syndrome and lymphoma.

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A three-month-old, female Cairn terrier presented with dermatitis on the periocular areas and lower jaw. Histopathologic examination was performed, and this dog was diagnosed as having Juvenile cellulitis. Although cephalexin and ketoconazole which were used prior to skin biopsy, were not effective, skin lesions were completely improved one month later with oral griseofulvin 20 mg/kg BID as immunoregulatory therapy.

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