A 10-year-old male miniature dachshund was presented with nasal bridge swelling with exudation and ulceration of the skin which simultaneously developed with the onset of diarrhea, lethargy, anorexic fever and abdominal pain. A histopathologic examination of skin biopsy specimens revealed focal nodular inflammation of the superficial to deeper dermis and subcutis. The predominant inflammatory cells were neutrophils and macrophages. Due to failure to find a causative agent, a diagnosis of sterile pyogranuloma was made, based on the pathological findings. Laboratory findings were consistent with pancreatitis, and the skin lesion improved with remission of pancreatitis. This suggests that sterile pyogranuloma may occur in relation to pancreatitis in dogs.