Malassezia Dermatitis is a common skin disease in dogs and likely to recur. Conventionally, azole-based antifungals have been used systemically or topically, however their use has been associated with problems of drug resistance and hepatotoxicity, and the shampoo therapy can be very difficult for some patients and owners (at home). There is a skin conditioning spray product which is used mainly by human care facilities which contains D-LYZOX as the chief active ingredient. We evaluated its clinical effectiveness against local lesions on nine dogs with suspected Malassezia Dermatitis, applying it twice a day for three weeks. One case had mild erythema at the start of treatment, but natural recovery occurred immediately. The dermatitis severity score and PVAS of the spray-treated dogs significantly decreased (P<0.01). The counts of Malassezia spp. in the lesions were lower, but the results were not statistically significant. In order to verify the contribution of the anti-inflammatory property of this formulation to the improvement of the dermatitis severity score and PVAS of the cases, we examined the effects of D-LYZOX on neutrophil adhesion as an in vitro parameter of inflammatory reaction. D-LYZOX inhibited lipopolysaccharide-induced adhesion of neutrophils obtained from a normal dog, suggesting the anti-inflammatory activity of D-LYZOX. These results suggest that this spray formulation containing D-LYZOX can improve the PVAS and dermatitis severity score of suspected local Malassezia dermatitis in dogs. We also discussed the need to clarify these clinical effects and their association with the suppression of neutrophil function.
Venom immunotherapy (VIT) provides an opportunity to reduce life-threatening reactions to venomous insect stings. VIT requires stabilization with human albumin. This report describes a Labrador Retriever that developed anaphylaxis during VIT induction. Intradermal testing (IDT) identified a human albumin hypersensitivity. Four years later, re-testing revealed a persistent hypersensitization to human albumin. To identify if VIT is a risk factor for human albumin sensitivity, IDT was performed in 4 honeybee allergic dogs being treated with VIT, with 6 healthy and 6 atopic dogs as controls. One other dog reacted to human albumin at the testing concentrations. This dog was being treated with VIT but had no clinical manifestations. VIT containing human albumin may lead to sensitization of this protein and anaphylaxis.
An 11-year-old intact male Miniature Dachshund was presented with localized alopecia on the right flank. Dermatological examination indicated telogen effluvium. Diagnostic imaging showed the enlargement of prostate gland, the intra-abdominal mass, and the subcutaneous cryptorchidism. An increased serum estradiol (E2) concentration and a decreased serum testosterone/E2 ratio indicated a secreting-testicular tumor. After orchiectomy and skin biopsy, a mixed Sertoli cell tumor and seminoma, with a cutaneous atrophy and telogen effluvium were diagnosed by histopathological examinations. Subsequently, decrease of serum E2 concentration and hair regrowth were observed. The present case was diagnosed as sex hormone alopecia caused by excessive estrogen from a Sertoli cell tumor.
A 4-year and 4-month-old, intact male, British Shorthair cat presented with multiple black-to-gray dome-shaped nodular lesions on both external ear canals and the concave surface of the pinna. The case was diagnosed as feline ceruminous cystomatosis based on a histopathologic examination of the nodular tissue. As the owner found it difficult to perform topical therapy at home, the cat was treated with ear cleaning and the administration of a topical ear gel containing 1% florfenicol, 1% terbinafine, and 0.1% betamethasone acetate three times at our clinic. The lesions almost completely regressed within 3 months, and no recurrence was observed within 6 months after the final medication.
Presumed sterile eosinophilic and granulomatous mural folliculitis and furunculosis was diagnosed in a goat. Dermatological findings included widespread, nonpruritic, bilaterally symmetrical exudation, crusting, alopecia, and thickened skin. Infectious causes were ruled out by negative histochemical stains and negative PCR for ovine herpesvirus-2 conducted on skin-biopsy specimens. There was a 50% reduction in the severity of the dermatitis with intramuscular injections of dexamethasone. A cause for the skin condition was not determined.