Forty dogs reffered to our dermatology clinic with long-term glucocorticoid administration were investigated. Twenty-seven dogs showed side effects such as polyuria and polydipsia, polyphagia, abdominal enlargement, panting, muscular atrophy, alopecia, prominent vasculature, calcinosis cutis, comedo, thin skin, and/or purpura. The most significant clinicopathological abnormality related with side effects were elevations of ALP and ALT. Elevations of ALP and ALT were in 74.1% and 55.6% respectively, in dogs with side effects, against 0.0% and 15.4% respectively in dogs without side effects. In ACTH stimulation test, both dogs with and without side effects showed a high incidence of adrenal suppression, 77.8% in dogs with side effects and 69.2% in dogs without them. Based on these findings, iatrogenic Cushing's syndrome should be evaluated in dogs treated with long-term glucocorticoid administration with both clinical findings, ALP and ALT, rather than with not only ACTH stimulation test.

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Rabbit syphilis was detected in all family members of household rabbits, namely parent rabbits and their 4 kits. The buck showed skin lesions a month after the mating and the doe 2.5 months after the mating (1.5 months after a delivery). The lesions of 4 kits were noticed at 2.5- to 3- month-old. Since rabbit syphilis is transmissible between the mating partners and from a doe to kits, the owner should be informed that the rabbits suffering from the disease and suspected to be infected should be eradicated from breeding in the future.

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Generalized demodicosis in two dogs was not controlled with oral Ivermectin 600 μg/kg SID, but Doramectin 600 μg/kg weekly subcutaneous injection produced dramatic improvement in these cases without any side effects.

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A dog with a classical course of toxic epidermal necrolysis is reported. A13-year-old, intact female West Highland White Terrier presented with fever and generalized epidermal necrosis. Histopathologic examination on the skin biopsy revealed epidermal coagulation necrosis, individual cell necrosis and satellite cell necrosis. The dog received intensive care, but died a few days later.

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