A dog suspected of having subcorneal pustular dermatosis, which had not responded to a treatment with dapsone and glucocorticoids, showed immediate remission after the initiation of cyclosporine. We found that the mRNA transcription levels of IL-8 and Th17 cytokines were high in the lesional skin. The results of gene transcription analysis suggest that Th17 cytokines were most likely involved in the pathogenesis of this case.

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The schnauzer comedo syndrome (SCS) is a visually distinctive dermatosis of miniature schnauzers. The SCS was diagnosed in 16 dogs, accounting for 0.2% of the canine dermatology cases and 0.04% of the canine hospital population over an 11-year-period. Interestingly, only 2 of the dogs were presented for only the SCS, and 12 (75%) of the owners had not previously noticed the SCS. Follow-up information was available for 10 (62%) of the dogs, and the SCS was unchanged for 3 months to 9 years.

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Idiopathic nasodigital hyperkeratosis (INH) is a visually distinctive disorder in dogs with a typical history and that are otherwise healthy. INH was diagnosed in 35 dogs, accounting for 0.4% of the canine dermatology cases and 0.1% of the canine hospital population over an 11-year period. English bulldogs, miniature poodles, miniature schnauzers, American cocker spaniels, and Doberman pinschers may be predisposed. Most dogs (71.4%) had only nasal involvement. The condition is usually asymptomatic, stable over time, and not reported to spontaneously resolve.

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