An 8-year-old male neutered domestic shorthaired cat was presented with three-month progressive dermatitis associated with pruritus and crusted lesions resembling cutaneous horns on all 4 paw pads. Firm crusted lesions extended up to 10 mm in some areas. Skin scraping revealed large numbers of mites and eggs compatible with Sarcoptes scabiei. A 4-mm skin biopsy showed marked diffuse ortho- and para-keratosis with intracorneal arthropods, bacterial cocci, acanthosis, and minimal perivascular mastocytic and suppurative dermatitis. The cat was treated with a single oral dose of afoxolaner combined with milbemycin oxime. Complete resolution of the clinical signs was observed on the second visit 14 days later. This unusual presentation resembled Norwegian scabiosis in humans.

Pemphigus foliaceus is an immune-mediated disease characterized by the formation of autoantibodies directed against epidermal intercellular junctions. Conventional treatments include the administration of immunosuppressive doses of glucocorticoids. The objective of this work is to present a cat with a histopathological diagnosis of pemphigus foliaceus that, due to its pre-existing cardiac pathology, was treated with oclacitinib (Apoquel^®, Zoetis, Buenos Aires, Argentina), a Janus kinase (JAK) inhibitor in order to avoid long-term side effects of oral corticosteroids.