A 9-year-old, castrated male mongrel dog had a mass in the footpad of the left hindlimb. Histologically, the tumor was composed of irregular tubuloacinar structures with desmoplasia, and apocrine secretion was observed on the surface of the neoplastic glands. Several neoplastic foci comprised of the cuboidal to polygonal epithelial cells showing a glandular proliferation and the spindle-shaped neoplastic cells proliferating adjacent to chondroid matrix. The epithelial cells showed a nuclear atypia and frequent mitotic activities. The epithelial cells were immunohistochemically positive for cytokeratin (AE1/AE3 and cytokeratin 8). The spindle-shaped cells showed intense immunoreactivity for vimentin but not for cytokeratins and smooth muscle actin. The tumor was diagnosed as mixed type of adenocarcinoma of sweat gland. Multifocal metastatic masses were observed in the lung 6 months after surgery.

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A one-year-old, female miniature Dachshund presented to our hospital for ovariohysterectomy. The health condition of the dog was unremarkable. Surgery was performed under general anesthesia using fentanyl, propofol, and isoflurane. The dog was discharged on the same day of surgery. After discharge, redness on the whole body appeared gradually. No abnormalities were found on the physical exam and blood work aside from the skin lesion. However, the dog was hospitalized and observed because of concerns about toxic shock syndrome. During hospitalization, a skin biopsy was performed and it revealed superficial vascular dilation with mild edema. The skin lesion spontaneously regressed approximately 10 days after the surgery, and has not reoccurred.

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Notoedres cati, a causative parasite in cats with scabies, is transmitted easily between feline species by contact with affected cats. This mite is also known to infest occasionally to canine species, although the mites belonging to Sarcoptidae generally show high level of host specificity. We experienced a 10-year-old, male maltese, which lived with a cat with scabies, having numerous mites and eggs characteristic to Notoedres cati on its skin surface. The dog was treated by injection with ivermectin subcutaneously and bathing with amitraz, but the dog required 3 months to obtain recovery of clinical signs and negative skin scraping for mange.

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Tumors on the epidermis of the trunk in 2 dogs (8-year-old, male Pomeranian dog and 9-year-old, female mongrel dog) were diagnosed as seborrheic keratosis. Histopathogical examination revealed that the epidermis was acanthotic and broad with a proliferation of the basaloid cells, arranged in glandular structures or cords that interconnected or surrounded the irregular keratin-filled cysts. The prominent hyperpigmantation was observed in the basal layer, and there was pigment clumping in the cysts. The histopathologic findings observed in the dogs are consistent with those in the acanthotic variant of seborrheic keratosis in humans.

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