A ethanol extract from Yellow batai (
Peltophorum dasyrachis) showed a suppressive effect on
umu gene expression of SOS response in
Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-
f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO
2 column chromatography and identified as surangin C (
1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the
umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID
50 value (50% inhibition dose) of compound
1 was 67.9 μM. On the other hand, compound
1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.
抄録全体を表示