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Volume 2 (1988)
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Volume 2, Issue 1
Displaying 1-12 of 12 articles from this issue
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Tomomi Kondou, Akira Akazawa, Junko Iwahara, Fumiyo Miwa, Yasuhei Odaj ...1988 Volume 2 Issue 1 Pages 1-6
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSIn order to understand the function of specific IgG, nasal secretion samples from 212 children with allergic rhinitis were studied to determine the relationship between cells in nasal smears and serum specific IgG and IgE antibodies. The relationship between eosinophils in nasal smears and serum specific IgE and IgG antibodies showed a strong correlation. The relationship between the appearance of mast cells in nasal smears and serum specific IgE also showed a strong correlation, but the relationship between these and serum specific IgG did not show a significant correlation. The appearance of neutrophils in nasal smears coincided with the presence of eosinophils in nasal smears. When the nasal provocation test was studied, the level of histamines in nasal secretions of patients, who were positive for serum anti-house-dust Mite specific IgG, was higher than in those who were negative, and changes in NCF in patients with neutrophils in their nasal smears were higher than those in patients without neutrophils. These findings support the view that, in allergic rhinitis, elements such as neutrophils and chemical mediators, eosinophils and serum specific IgG, mast cells and serum specific IgE, interfere and mix in a very complex manner, creating a more complicated understanding of the status of the disease.View full abstractDownload PDF (887K) -
Motoko Mizojiri, Yukiaki Sanada1988 Volume 2 Issue 1 Pages 7-12
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSFifteen asthmatic children, whose prick tests to tobacco smoke were all negative, were exposed to sidestream cigarette smoke (passive smoking) for 30 minutes in a room in which the carbon monooxide concentration was 7-8ppm. At the time of study, the patients were asymptomatic and had normal or nearly normal respiratory function. Patients showed an increase of 0.21per cent in carboxyhemoglobin as a result of the passive smoking. Passive smoking produced almost no change in the flow volume curves. However, there was a decrease in functional residual capacity (FRC), thoracic gas volume (TGV) and specific airway conductance (SGaw) More interestingly, airway resistance (Raw) showed a continuous increase, even at 6 hours after passive smoking. These findings suggest that passive smoking does not induce allergic reaction to tobacco smoke, but does stimulate bronchial hyperactivity in asthmatic children.View full abstractDownload PDF (939K) -
Yasuhei Odajima, Akira Akazawa, Tomomi Kondou, Youji Iikura, Hideji Mi ...1988 Volume 2 Issue 1 Pages 13-17
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSAminophyllin is widely used for the teating acute exacerbation of asthma, It is well known that serum pH varies during acute exacerbation of asthma and that serum pH influences the protein binding of theophylline. Therefore, total and free-theophylline and venous pH were measuredin children with acute exacerbation of asthma during pre-and post-aminophylline drip infusion.
1. Free-theophylline was correlated with total theophylline.
2. The serum pH (7, 337 to 7, 477) had no influence on theophylline protein binding.
3. % free theophylline was correlated with total theophylline (r=0, 351, P<0.01).
4. We studied the effect of age on % free theophylline, % free theophylline was 40.4±4.1% for 1 to 7 year olds, 33.1±3.9% for 6 to 11 year olds and 31.1±17.7% for those over 12 year olds. There was a positive relationship between age and the fall of % free theophylline, however, there was no correlation between % free theophylline and age.View full abstractDownload PDF (734K) -
A COMPARISON BETWEEN PERIODS WITH AND WITHOUT ASTHMA ATTACKSTaiji Kunitomi, Masanori Ikeda, Nobuyuki Kodani, Keiko Tachibana, Shin ...1988 Volume 2 Issue 1 Pages 18-22
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSTheophylline serum concentrations (TSC) in ten asthmatic children during RTC therapy were closely examined in order to compare the values for periods with and without acute asthma attacks.
1) Average TSC during the periods without attacks (fluctuation from day to night) remained above 10μg/ml. on the contrary, during acute attacks, TSC decreased significantly (P<0.05) within two hours and nine to ten hours after an 8:00 a.m. dose. The tendency to decrease was also observed within one to six hours after an 8:00 p.m. dose. TSC in the above three cases was 5 to 9μg/ml.
2) Twenty moderately severe to severe attacks (71%) out of 28 in the ten asthmatic children who were brought to the hospital for emergency took place when TSC was at a minimum, a few hours before and after dosing.
It is concluded that if asthmatic children on RTC therapy who have a TSC level higher than 10μg/ml in the period without attacks, yet have frequent asthma attacks, TSC value should be examined again at the time of frequent attacks.View full abstractDownload PDF (757K) -
Toshihiko Obata, Takuro Masaki, Yoji Iikura, Katsuyuki Miyasaka1988 Volume 2 Issue 1 Pages 23-27
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe WINDMILL®, a device of measuring forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), was compared with a hot-wired autospirometer (AS-1500, Minato Ikagaku, Tokyo, Japan). The WINDMILL® showed FVC and FEV1 with calculating the rolling numbers of eight windmills, which were 10mm wide and 30mm length, by a forced expiration. Fifteen healthy subjects, aged 23 to 33 years, showed good correlations except FVC in males (r=0.60) between two devices. Thirty four asthmatic patients, aged 6 to 22 years, showed correlations in FVC (over 2.0L: r=0.88, less than 2L: r=0.12) and in FEV1 (over 1.5L: r=0.97, less than 1.5L: r=0.67).
This device showed lower values in both FVC and FEV1 compared to a hot-wired autospirometer especially in the case of subjects with low flow levels. In elder children, however this can be useful because of its producibility and good correlations with the autospirometer.View full abstractDownload PDF (753K) -
Hiroyuki Inui, Toshihiko Obata, Tadashi Uekusa, Masaru Kishida, Kazuhi ...1988 Volume 2 Issue 1 Pages 28-35
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSIsoproterenal therapy was performed on 118 childhood status asthmaticus patients (continuous inhalation 94 cases, continuos drip-infusion 24 cases).
INHALATION: With respect to time, dyspnea and heart rate decreased in all cases. No side effects were observed. Continuous inhalation in thought to be a safe and effective therapy for status asthmaticus, and to be worthwhile attempting before steroid therapy.
DRIP INFUSION: Compared to the inhalation patients, more severe children were chosen. This therapy is effective as an alternative method for intubation, but it requires much more equipment and medical staff compared to continuous inhalation. It is also important to prepare properly prior to intubation.View full abstractDownload PDF (1187K) -
COMPARATIVE STUDY WITH SAIBOKUTOHiroshi Odajima, Minoru Baba1988 Volume 2 Issue 1 Pages 36-40
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSTwenty-six patients with asthma were treated with Syoseiryuto for three months or longer. In 66.7% of the cases, it was determined to be useful.
In order to be useful for the treatment of asthma, using more than 0.15mg/kg of body weight of Syoseiryuto is recommended. Cases appropriate for Syoseiryuto were considered to have an atopic history with high serum IgE levels and a tendency toward nasal trouble. On the other hand, those for Saibokuto were considered to have a tendency toward infection-induced asthma, hyperactivity, sweating and fatigue, and abdominal pain and cold. The importance of selection of cases for the indication of these drugs is suggested. It is suggested also that proper selection of cases for these drugs will render them more effective.View full abstractDownload PDF (882K) -
Minoru Baba, Hirotaro Kawai, Takehiko Matsui, Tetsuo Kubagawa, Yoshiro ...1988 Volume 2 Issue 1 Pages 41-48
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSChildren with atopic factors develop allergic diseases such as atopic dermatitis (AD), asthma (BA) and allergic rhinitis (AR) one after another (allergy march). Ketotifen was given to 124 children with allergic diseases aged 6 month to 15 years for 12 weeks in order to investigate the clinical efficacy of ketotifen on the progress of allergy march.
Symptoms were improved in 91.1% (i. e., markedly improved in 12.9%, moderatery improved in 47.6% and slightly improved in 30.6%), unchanged in 8.9%, and aggravated in 0%. Favorable results were obtained (p<0.001) from the attack score, severity of rhinitis and severity of AD of 58 cases of combined BA, AR, and AD, 32 of combined BA and AR and 34 of combined BA and AD. Further, sneezing and pruritus were alleviated significantly (p<0.05, p<0.001). These results suggest that ketotifen has a wide variety of pharmacological effects and can prevent the progress of allergy march.View full abstractDownload PDF (1158K) -
Kimio Tajima1988 Volume 2 Issue 1 Pages 49-51
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSLimulus positive substances in Dermatophagoides farinae (Df) extracts were studied. Df antigens were extracted by acetone precipitation according to the method of Le Mao et al. Limulus positive substances were detected in crude Df antigen, Df50d and Df80d. The weights of limulus positive substances were estimated to be approximately 10%, 1% and 0.01% of the protein content respectively. The limulus positive substances were eluted at void volume using Sephadex G-100 column Gel-filtration.View full abstractDownload PDF (483K) -
Takehiko Matsui, Youko Miyabayashi, Kunio Ichikawa, Kouichi Yamaguchi, ...1988 Volume 2 Issue 1 Pages 52-59
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSWe have experienced twenty nine cases of death from asthma who had visitted the department of pediatrics of Doai Memorial Hospital between 1965 and 1987. These cases were analised. They were 18 males and 11 females. The mean age at death was 12.4 years-old and we found that death in later childhood and adolescence had been increasing since 1973. The duration from final attack to death was very short: less than 1 hour: 20.8% and less than 2 hours 50%. About half of them couldn't arrive at hospital. Ten cases died within one year after cessation of long term systemic administration of steroid. The causes of death are as follows: asphyxia: 23 cases (one complicatting with aspiration, one withdrawal syndrome of steroid, and one subendocardial haemorrhage and two pneumothorax cases), anaphylaxic shock to ACTH 1 case, shock to a stimilant: 1 case, following emergency operation: 1 case and unknown: 3 cases.View full abstractDownload PDF (1275K) -
Kiyoshi Nishikawa1988 Volume 2 Issue 1 Pages 60-68
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSAlthough it has been difficult to control severe and intractable asthma patients, even adults, using conventional therapy, a new treatment featuring regular use of DSCG and salbutamol inhalation produced an improvement in the clinical symptoms and the quality of life for almost all patients with asthma.
When the clinical symptoms for 3 months before regular use were compared with those for three months after use, asthma attack scores for severe and intractable patients decreased from 22.8 to 10.2, and from 71.7 to 17.4, respectively.
Frequency of emergency room visits decreased from 12.3 to 3.1 times in 12 severe patients and from 27.3 to 1.1 times in 7 intractable patients. Mean dosage of corticosteroid (prednisolone) for intractable patients decreased from 460.7mg (range 150 to 945mg) to 74.2mg (range 0 to 415mg).
It is concluded that the regular use of DSCG and a β2 agonist not only prevented asthmatic attacks, but also induced an improvement in intractable patients by prolonging bronchodilatation, inhibiting the effect against bronchial inflammation and reducing bronchial hypersensitivity.View full abstractDownload PDF (1331K) -
[in Japanese], [in Japanese]1988 Volume 2 Issue 1 Pages 69-72
Published: July 25, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (287K)
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