The effect of inhaled beclomethasone dipropionate (BDP) using the spaser (InspirEase) was studied in 24 children (aged three to six years) with moderate to severe bronchial asthma. Seventeen patients were receiving BDP for six weeks after control 2 weeks and seven control subjects were receiving no corticosteroid therapy.
1) Frequency of minor attack of bronchial asthma was decreased within two weeks after this therapy started, especially in children receiving 300μg/day of BDP.
2) Peak flow rate was increased within first two weeks in many cases.
3) Serum cortisol levels were decreased in some cases. Oral candidiasis was not observed in any patients. These data suggested that BDI therapy using the spacer was effective on control of moderate to severe childhood asthma.

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Four cases of severely asthmatic children aged 9 to 15 were studied with the aid of peak flow monitoring during inhalation of Beclomethasone Dipropionate Inhaler (BDI; 100μg×2/day) which was regularly administered for six weeks.
The study examined asthmatic symptoms, peak expiratory flow rate (PEF) and diurnal variation in PEF, which means (maximum-minimum)×100/maximum.
1) Although PEF and asthmatic symptoms, varied from case to case, diurnal variation in PEF was increased in every case. The indication for BDI should be based on an integration of such information obtained from peak flow monitoring with asthmatic symptoms.
2) The response of PEF to BDI was different for each case. However, peak flow monitoring could detect an overdosage or an underdosage.
3) It is thus concluded that peak flow monitoring is useful to determine the indication for or the effect of BDI and to control the dosage.

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Twenty-five children with a history of egg sensitivity, e. g. exanthema, urticaria and diarrea and/or who had a specific IgE antibody for egg-white, were evaluated for receiving measles vaccine or measles, mumpus and rubella vaccine (MMR vaccine)
Skin tests were performed with egg-white and a 1:10 or 1:100 dilution of measles or MMR vaccine. Skin prick test with egg-white was positive in all eight children who had a history of egg sensitivity. All twenty-three children with a negative reaction to the skin test with the diluted vaccines were immunized in the routine way with no immediate adverse reactions. Two children, who had positive reactions to the intradermal skin test with the diluted vaccine, were safely immunized with desensitization by subcutaneous administration of the vaccine as described previously by Herman, et al.
These studies suggest that children with a history of egg sensitivity should be screened with the skin test with a dilution of measles or MMR vaccine prior to immunization with measles or MMR vaccine, and children who have a positive reaction to the skin test should be immunized according to a desensitization protocol.

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A survey with question sheets was conducted on the supporters of 11392 elementary school cildren in Naha City regarding whether they have symptoms of allergic diseases, especially atopic dermatitis, bronchial asthma, etc, and the hereditary relations of these diseases.
As a result, after the return to Japan 20 years ago, it tas been found that children' s allergic diseases, especially atopic dermatitis, is on an increasing tendency, though they are smaller in number than the national average. Atopic dermatitis is about 1/3 of the national average.
Regarding the hereditary relation, the incidence of the allergc diseases in children is very high if their parent or grandparent has this disease. But many children have the allergic diseases in spite of no such hereditary relations being recognized in their families.
Characteristic about the atopic dermatitis in the children in Okinawa Pref. is that in many children, this disease is aggravated during summer, which is different from the national tendency of this disease.

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In order to evaluate the propriety of newly proposed standard values of serum IgE levels, I examined the changes of serum IgE levels in 153 cases of infants and children who were suspected to be allergic. In the detection of high IgE cases by the proposal, the rates of the false positive and the false negative were 20.5% and 10.2%, respetively. So I considered that “ray zone” should be prepared beneath the border line of the proposed standard value, in order to reduce these false positive and false negative rates.
The range of the “gray zone” were; ‹6M: 2-5, 6-11M: 4-10, 1Y: 8-20, 2Y: 15-40, 3-4Y: 30-70, › 5Y: 50-100IU/ml. And children whose serum IgE levels were over the zone, should be considered to be genetically high IgE, and may be allergic or may become allergic thereafter. And in cases within the “gray zone”, the genetical IgE group of the child should be considered undecided at that time.

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Bronchial asthma in childhood has much psychosocial effects to the patients and their families during their illness.
We found the several reports of parental perceptions and attitudes towards their children's asthma, but any report of siblings has not been found. In this study we investigated one hundred of siblings' perceptions and attitudes towards asthma by the questionnaires. (How do you help your siblilngs during their asthmatic attacks? How do you feel during the asthmatic attacks? What's the cause of their asthma? How do you think about the prognosis of asthma? Have you ever experienced any difficulties in being siblings of them? etc.)
As a result, the influence of asthmatic attack on sibilngs were huge; sleep disturbance, wasting time for patients. Answers of siblings let us know new aspects of patients' problems. To understand patients' psychosocial background, not only patients but siblings and parents need our approaches about asthma.

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We have examined CV_R-R values in 195 school children in an elementary school. These children were categorized into 5 groups (control, BA, AD, AR and triple allergies) from the informations of a questionnaire.
The CV_R-R values in the allergic groups were lower than those in the control group, although these were not significant.
We also measured CV_R-R values in 19 BA-patients at the out patient department of Saga Medical School and 25 hospitalized BA-patients at Minami Fukuoka Chest Hospital.
The CV_R-R values in the hospitalized patients were significantly lower than those in the control. These results indicate that parasympathetic nerve function is not always activated in the patients with allergic diseases including asthma.
Among these hospitalized patients, the CV_R-R values in the patients who regularly took β-stimulant were lower than those in patients without β-stimulant, indicating that a regular use of β-stimulant decreased CV_R-R values.
Next, we examined CV_R-R values in 6 patients who took a swimming class for 8 weeks. In 5 of 6 patients, the values decreased after completion of the training.
It may suggest a possibility that parasympathetic nerve function was suppressed by the swimming training for 8 weeks.

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