Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
Online ISSN : 1882-2738
Print ISSN : 0914-2649
ISSN-L : 0914-2649
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Volume 21, Issue 1
Displaying 1-24 of 24 articles from this issue
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    2007 Volume 21 Issue 1 Pages 7
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.7
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    2007 Volume 21 Issue 1 Pages 8-13
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.8
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    [in Japanese]
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  • TH-2 TYPE CYTOKINE INHIBITOR
    Shigemi Yoshihara
    2007 Volume 21 Issue 1 Pages 14-20
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.14
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    [Introduction] It is necessary to suppress the allergic march in infants who have food allergies (FA) or atopic dermatitis (AD). To determine whether Th2-type cytokine inhibitors (IPD) are useful for the primary prevention of asthma, we analyzed the allergic march on the basis of the Th1/Th2 ratio, examined the effect of IPD.
    [Material and Methods] 1. The Th1/Th2 ratio was measured in children with AD to examine differences among various types of allergic diseases. 2. To study whether IPD was effective for the primary prevention of asthma, the incidence of initial wheezing was examined in 32 children with FA and AD who were assigned to receive IPD or an Histamine H1-blocker. The changes of Th1/Th2, total IgE level and eosinophil count in peripheral-blood after treatment were compared.
    [Results] 1. The Th1/Th2 ratio was low even at the stage of AD a few months after birth. 2. The incidence of initial wheezing after treatment was significantly lower in IPD group than in the Histamine H1-blocker group. Moreover, the eosinophil count was significantly decreased and Th1/Th2 ratio was significantly increased in IPD group, as compared with the H1 group.
    [Conclusion] IPD given at the stage of food allergy several months after birth is useful for primary prevention of atopic asthma.
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  • [title in Japanese]
    [in Japanese]
    2007 Volume 21 Issue 1 Pages 21-27
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.21
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  • [title in Japanese]
    [in Japanese]
    2007 Volume 21 Issue 1 Pages 28-31
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.28
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  • DEGRADATION OF WHEAT ALLERGEN IN SOY SAUCE BREWING
    Makio Kobayashi, Soichi Tanabe, Shoichiro Taniuchi
    2007 Volume 21 Issue 1 Pages 96-101
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.96
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    Soy sauce is a traditional fermented seasoning of Japan and is available throughout the world. Wheat and soybeans are the two main raw materials of soy sauce, and soy sauce also contains a high concentration of salt. Since wheat allergy is considered a serious problem globally, it is significant to examine the allergenicity of soy sauce. By immunoblotting, inhibition ELISA and direct ELISA using sera from five children with severe wheat allergy, it was clearly demonstrated that wheat allergens were degraded into amino acids and peptides that lose the IgE-binding ability in both salt-soluble and salt-insoluble fractions of soy sauce during fermentation. In the brewing process of soy sauce, first salt-insoluble wheat allergen was solubilized to salt water during the koji stage (mold cultivation and enzyme production), and second both the resultant salt-solubilized and initially salt-soluble wheat allergens were completely degraded during the moromi stage (fermentation) by microbial proteolytic enzymes. Furthermore, it was demonstrated by immunoblotting, inhibition ELISA and direct ELISA that no wheat allergen was detected in ten specimens of commercial soy sauce produced in Japan.
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  • COMPARISON THE UTILITY OF PRANLUKAST WITH SUSTAINED RELEASE THEOPHYLLINE PRODUCT IN THE INITIAL TREATMENT PERIOD OF EXACERBATION OF BRONCHIAL ASTHMA IN CHILDHOOD
    M Kishida, R Kuroiwa, H Nakazono, T Koshibu, I Suzuki, J Nakazato, H D ...
    2007 Volume 21 Issue 1 Pages 102-108
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.102
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    Pranlukast, a specific cysteinyl leukotriene receptor antagonist, has been shown to have a action of bronchodilataion in a short time. This study was undertaken to compare the utility of pranlukast with sustained release theophylline product in the initial treatment period of exacerbation of bronchial asthma in childhood.
    Sixty asthmatic children who have suffered attacks for two weeks or more, were enrolled to receive pranlukast (7mmg/kg) or sustained release theophylline product (10mg/kg) in a randomized fashion. They were observed for the observation period of two weeks and administering period of 4 weeks to document the effects on the attack score and the QOL score.
    The attack score of pranlukast group was gradually improved better than that of sustained release theophylline statistically in less than 4 years old. The QOL score of both groups decreased in the same way.
    Therefore, compared with sustained release theophylline, pranlukast is more useful in the initial treatment period of exacerbation of bronchial asthma in childhood.
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  • VALIDITY OF ULTRASONOGRAPHY IN THE DIAGNOSIS OF ACUTE MAXILLARY SINUSITIS IN CHILDREN
    Takatsugu Kojima, Toshimi Kojima, Shoichiro Taniuchi, Kazunari Kaneko
    2007 Volume 21 Issue 1 Pages 109-115
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.109
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    To clarify the validity of ultrasonography (US) in sagittal view in the diagnosis of acute maxillary sinusitis (AMS) in children, we studied the following.
    1. US findings of normal maxillary sinuses were examined in 26 healthy volunteer (aged: 0-29). Maxillary sinuses will be detectable by US in patients more than 2 or 3 years old.
    2. US findings of maxillary sinuses in the patients with acute rhinosinusitis were divided into three types as follows: Type I: positive air bubbles in the cavity, Type II: visualisation of the posterior wall of the maxillary sinus, Type III: visualisation of the posterior wall and back-echo of the posterior wall.
    3. Radiographic and US findings were compared in 29 patients with clinically suspected AMS. All patients who had Type III US findings showed radiographical AMS.
    4. Nine patients who had AMS were treated by antibiotics. Positive US findings disappeared by antibiotic therapy. From these findings, we conclude that the detection of positive back-echo of the posterior wall in US findings is a useful marker in the diagnosis of AMS in children.
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  • INTRACTABLE ASTHMA IN JAPANESE CHILDREN, COMMITTEE REPORT IN 2005
    T. Matsui, T. Akasaka, A. Akazawa, M. Ikeda, S. Ito, M. Ebisawa, H. Od ...
    2007 Volume 21 Issue 1 Pages 124-127
    Published: March 01, 2007
    Released on J-STAGE: December 04, 2007
    DOIhttps://doi.org/10.3388/jspaci.21.124
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    Prevalence rate of intractable asthma was studied among the patients of members of the Japanese Society of Pediatric Allergy and Clinical Immunology and hospitals of medical school in October 2005. The information of seven hundreds and fifty two hospitals and private clinics was studied. The oral steroid dependent asthma patients were 0.07% in hospitals and 0.04% in private clinics. The patients needed more inhaled corticosteroid than usual uses were 1.52% in hospitals and 0.75% in private clinics except the oral steroid dependent asthma. The patients frequently admitted hospital and needed intravenous steroid more than 5mg/kg/day in predonisolone were 0.57% in hospitals and 0.12% in private clinics except the former two categories.
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