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Volume 1 (1987)
- Issue 2 Pages 1-
- Issue 1 Pages 1-
Volume 1, Issue 2
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[in Japanese]1987 Volume 1 Issue 2 Pages 1
Published: December 25, 1987
Released on J-STAGE: April 30, 2010
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1987 Volume 1 Issue 2 Pages 2-8
Published: December 25, 1987
Released on J-STAGE: April 30, 2010
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1987 Volume 1 Issue 2 Pages 9-11
Published: December 25, 1987
Released on J-STAGE: April 30, 2010
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1987 Volume 1 Issue 2 Pages 12-38
Published: December 25, 1987
Released on J-STAGE: April 30, 2010
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Hajime Watanabe1987 Volume 1 Issue 2 Pages 39-43
Published: December 25, 1987
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSOne hundred and thirty nine asthmatic children and twenty non asthmatic children were studied. The acetylcholine and histamine inhalation tests were performed according to the standarized method.
1) Reproducibility of MEFV curve in children was examined. FEV1.0, an index of airway obstruction, was reliable.
2) Over all age a 20% fall in FEV1.0 was adequate to examine the asthma provocation in the inhalation tests.
3) RT-Ach and RT-Hist were correlated with severity.
4) The acetylcholine and histamine tests were clinically useful in asthmatic children.View full abstractDownload PDF (723K) -
Yuhe Hamasaki, Tomohiro Ichimaru, Sumio Miyazaki1987 Volume 1 Issue 2 Pages 44-47
Published: December 25, 1987
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe inhibitory actions of azelastine hydrochloride (AZ) and AA-861 against 5-lipoxygenase were examined and compared with that of gossypol acetic acid (GAA) by measuring the calcium ionophorestimmulated synthesis of LTB4 in human polymorphonuclear calls (PMN) and rat pulmonary-lavaged cells, most of which were macrophages. Fifty percent inhibition of LTB4-synthesis (IC50) was obtained with GAA at 2.4×10-6M in human PMN and rat pulmonary lavaged cells. The IC50 of AZ was 2.6×10-5M in PMN and 2.1×10-5M in rat pulmonary lavaged cells. It is aboutone tenth as potent as GAA.
The IC50 of AA-861 was 2.3×10-6M in human PMN and 0.67×10-7M in pulmonary lavaged cells. The potency of inhibition was equal to that of GAA in human PMN and 35.8 times as strong as that of GAA in pulmonary lavaged cells.View full abstractDownload PDF (563K) -
Noriko Shiigai, Kimiaki Uchimura, Tomoko Otani, Keiko Shimoda, Kaeko Y ...1987 Volume 1 Issue 2 Pages 48-53
Published: December 25, 1987
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSOne hundred and sixty nine asthmatic children, 117 boys and 52 girls with mean age of 8 years 11 months, were given 16 to 19mg/kg/day of a sustained-release theophylline(Theo-Dur), and were divided into two groups, 68 with every 12-hour (b. i. d.) and 101 with every 8-hour (t. i. d.) dosage regimen. At the end of 4 days on these dosage, the serum theophylline concentrations were measured by the enzyme immunoassay.
The younger children less than 8 years of age had 4-hour postdose levels of 14.1±4.9μg/ml (b. i. d.), 11.8±3.6μg/ml (t. i. d.) and older children over 9 years of age having 15.5±6.3 (b. i. d.) and 14.0±4.6 (t. i. d.) respectively. There were significant positive correlations between dosage and serum levels among different age and dosage groups.
Therapeutic level of 10 to 20μg/ml was observed more often in t. i. d. than b. i. d. regimen, and the level of over 20μg/ml and single case of nausea and vomiting seen in b. i. d. group.
In conclusion, even sustained-release theophylline preparation can be given every 8-hour to asthmatic children who do not respond to 12-hour dosage regimen clinically with fluctuation of the serum level. Suggested schedule based on the serum concentration followed.
Age Dosage/12-hour 8-hour
Less than 8 years 6-7mg/kg/dose 4-5mg/kg/dose
Over 9 years 5-6 3-4View full abstractDownload PDF (1051K) -
Kenzo Fukushima, Yoshihiro Matsumoto, Masaru Kishida, Kazuo Shiraki1987 Volume 1 Issue 2 Pages 54-59
Published: December 25, 1987
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSNK activity and LAK activity were estimated in normal mononuclear cells treated with Aminophylline (AMIN), Procaterol hydrochloride (PROC) or Azelastin hydrochloride (AZPT).
1. NK activities were suppressed in a dose-dependent manner by treatment with AMIN or PROC. However, the suppression was only slight at pharmacological doses, and the decreased NK activities were restored to normal ranges by Interferon-α (IFN-α) administration.
No Suppression was observed with AZPT treatment.
2. LAK activity was suppressed in a dose-dependent fashion with AMIN treatment.
However, suppression was slight at pharmacological doses, with the decreased LAK activity being restored to normal ranges by IFN-α administered at the effector phase.
No Suppression was observed at pharmacological doses with PROC or AZPT treatment.
3. NK cell related surface markers (Leu-7, Leu-11 and OKM-1) showed no changes during treatment with AMIN at pharmacological or higher doses.
4. The decreased NK activity observed in asthmatic children was correlated with the increased serum concentration of theophylline.View full abstractDownload PDF (1064K)
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