The determination of erythrocyte CR1 in the blood circulation was made using the IAHA method in 69 patients with atopic dermatitis whose ages ranged from two months to 48 years. The following results were obtainded:
1) In patients with atopic dermatitis, there were 21 cases (30%) with negative CR1 activity and thus the frequency was significantly high. On the other hand, in 146 healthy control cases, there were only 12 cases (8%) of negative CR1 activity. Therefore, the number of cases of negative CR1 activity was significantly higher in patients with atopic dermatitis.
2) When such cases were classified by age, it was found that the number of negative cases was higher in newborns of infants in comparison with the controls but that the ratio drew nearer to that in the controls after the age of two to three years.
3) No obvious trend was noted between the negative CR1 activity cases and the positive cases regarding the lesions on the skin, atopy in the air passage and the prognosis.
4) More negative CR1 activity cases were observed in the serum IgE normal group.
5) No definite trend of erythrocyte count, hemoglobin, eosinocyte count, C3, C4 and immunocomplex was necessarily observed between the negative and positive CR1 activity cases.

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We reported a 11-year-old boy with hypersensitivity pneumonitis diagnosed by BAL and TBLB. The precipitating antiboby against Trichosporon cutaneum was observed in the serum of this patient. In mycological study of house dust, Trichosporon cutaneum was isolated from his house, and the same respiratory symptoms recurred when he returned to his home. Based on these results, Trichosporon cutaneum was considered to be the most suspicious etiologic agent. Examination of his family revealed that two another members had positive precipitating antibodies against Trichosporon cutaneum and one of the two had had similar symptoms to this patient for the past two years.
To prevent the recurrence and chronic change of summer-type hypersensitivity pneumonitis, it is important to perform the mycological studies and to instruct their family about the cleaning of their houses correctly.

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Airborne fungal flora in the hospital and 4 homes of hospitalized asthmatic childen were examined using a slit sampler. The indoor airborne fungal flora detected on the potato dextrose agar medium (PDA) was different from that detected from the outdoor air samples. Some kinds of fungi were fuond only in the indoor air samples. The average number of fungal colonies in the indoor air samples from homes (42.1) was higher than that in the indoor ones from the hospital (18.6) (p<0.001). One patient had often had attacks when he came home. One of the reasons for these attacks was supposed to be due to his exposure to more fungal elements in the home than in the hospital. The prevalence of an osmophilic fungus Wallemia sebi was studied: 5.1% of all indoor fungal colonies and 3.0% of all outdoor ones were detected on the dichroran glycerol agar medium (DG18), while 0.09% of all indoor fungal colonies and none from outdoor ones were detected on the PDA.
Airborne fungal flora in 25 homes of non-asthmatic children was examined using the DG18 to detect osmophilic fungi. In the indoor air samples, Cladosporium had the highest incidence, followed by Penicillium, Alternaria, yeasts, Epicoccum and Aspergillus. W. sebi was the seventh most prevalent in the indoor air samples and the eleventh in the outdoor ones. The incidence of W. sebi in the 25 homes was significantly higher in the indoor air samples than in the outdoor ones (χ²test p<0.01). It was suggested that W. sebi and other osmophilic fungi might be predominant in the indoor air.

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We investigated the increase of IgE RIST titer and eosinophile counts in 56 0-year allergic children. (male 31, female 25; wheezy children 11, children with atopic dermatitis 21, wheezy children with atopic dermatitis 21, and other allergic children 2)
We measured IgE RIST titer by using the radioimmunoassay Sephadex method.
We recognized that there were many male children among the wheezy children with atopic dermatitis group, and many female children in the atopic dermatitis group.
There was a strong trace of allergic heredity in the patients. IgE RIST titer in allergic children over 8 months, was higher than that of allergic children under 5 months. But the eosinophile counts of those allergic children did not show such a tendency. This was becouse there were high eosinophile counts for the group containing children under 5 months.
Then we set up the standard level of both examination values.: IgE RIST 30IU/ml: eosinophile count 200/mm³.
By these standard levels, we investigated the 3 groups; the wheezy children group, the atopic dermatitis group, and the wheezy children with atopic dematitis group. The high average ratio over the standard level was as follows: atopic dermatitis group>wheezy children with atopic dermatitis group>wheezy children group.

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A 36-year-old male patient with serious atopic dermatitis and prurigo was treated with eicosapentaenoic acid (EPA) for a period of 2 years.
The results were as follows.
The symptoms were improved within 2 months after the treatment with EPA.
The number of eosinophiles declined from 16-24% to 6-8% after the treatment with EPA.
Serum IgE (RIST) level dropped from 15, 000U/ml or higher to 8, 000U/ml within 2 years.
The frequency of the asthmatic attack also decreased and the respiratory function such as V50 and FEV 1.0 was improved within 2 months after the treatment with EPA.

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We measured total IgA, IgM and ovalbumin (OA) specific IgA, IgM antibodies inbreast milk for 88 samples from 48 mothers, Total IgA and IgM levels were the highest on the second day after delivarly and these levels decreased rapidly with time, The levels of OA-specific IgA and IgM antibodies also revealed same tendency as those of total IgA and IgM.
Furthermore, OA-specific IgA antibody decreased first and then increased gradually after the peroral challenge with an egg.

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Two adolescent cases were diagnosed as exercise-induced anaphylaxis (EIA) with urticaria, dyspnea and loss of consciousness after exercise.
A thirteen year old boy had 5 episodes of generalised urticaria, dyspnea and confusion after running since 11 years of age and responded mildly to bicycle ergometer. A sixteen year old asthmatic girl had several episodes of swelling on eyelids, papular rash on extremities within 2 hours after eating and followed by generalised urticaria, dyspnea and confusion after running since 14 years of age, but didn't respond to bicycle ergometer. Both cases showed typical sympotoms of EIA in adolescent age with high serum IgE and atopic diathesis.

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