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Volume 4 (1990)
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 4, Issue 2
Displaying 1-7 of 7 articles from this issue
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1990 Volume 4 Issue 2 Pages 103-150
Published: December 25, 1990
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (9538K) -
1990 Volume 4 Issue 2 Pages 151-153
Published: December 25, 1990
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (502K) -
1990 Volume 4 Issue 2 Pages 154-158
Published: December 25, 1990
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (846K) -
Makoto Shigeta, Akihiro Morikawa, Kouji Tateno, Toshisada Kimura1990 Volume 4 Issue 2 Pages 160-165
Published: December 25, 1990
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSWe studied the effects of azelastine and disodium cromoglycate on bronchial responsiveness in 26 asthmatic children, using histamine inhalation challenge.
We divided the subjects into three groups. For 12 weeks, the 1st group of patients inhaled 20mg of disodium cromoglycate 4 times daily, the 2nd group took oral administrated 2mg of Azelastine twice daily and the 3rd group had no antiallergic drugs. Histamine inhalation challenges were performed before and at the end of treatment period. There was no statistical difference between the results obtained before and at the end of treatment in the group which didn't have antiallergic drugs. But the threshold of histamine had significantly increased after treatment of DSCG and Azelastine (p<0.05, p<0.01 respectively).
Our results suggested that not only the inhaled disodium cromoglycate but also the administration of azelastine had the effect of attenuating the bronchial hyperresponsiveness of asthmatic children.View full abstractDownload PDF (783K) -
Ken-ichi Akimoto, Yoji Iikura1990 Volume 4 Issue 2 Pages 166-171
Published: December 25, 1990
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSWe measured ovalbumin in mother's milk using new method of fluoroenzyme immunoassey. Using this system, we can detecta ovalbumin in mother's milk.
In the milk samples of 40 mother's who had not eaten any egg, no ovalbumin could be detectd except in one sample. In the milk samples of 20 mother's who had eaten two eggs, ovalbumin was detected in 14 samples and the maximum concentration of ovalbumin was 1.8-170.0ng/ml. The concentration reached its maximum between 30-480 minutes after the mother had eaten the 2 eggs. There was no correlation between either the maximum concentraion or the period taken for the maximum ovalbumin concentration to be reached and infant's antibodies in the serum which include total IgE, specific IgE, specific IgG and IgA.View full abstractDownload PDF (786K) -
A COMPARATIVE STUDY BETWEEN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND RADIOIMMUNOASSAYAyami Iwasaki, Toshio Katsunuma, Kenichi Akimoto, Akira Akasawa, Ayako ...1990 Volume 4 Issue 2 Pages 172-177
Published: December 25, 1990
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSMite antigen-induced histamine release was examined using whole peripheral blood from asthmatic patients. Released histamine concentrations were determined by both high performance liquid chromatography (HPLC) and radioimmunoassay (RIA) and the values were compared stastistically.
Samples were taken from 9 children (5 males and 4 females; Age 6-13 years) with IgE RAST Score 4 positive to housedust mite, Dermatophagoides farinae.
Three different histamine levels, histamine release challenged with mite antigen at concentrations ranging from 10-4 to 100μg/ml, spontaneous histamine release, and total histamine levels taken by repeated freeze/thawing, were measured by both HPLC and RIA.
There was a strong correlation (r=0.948, n=63, p<0.001) between the logarithm of values determined by RIA and those determined by HPLC. In addition, the RIA method needs only about 1ml of whole peripheral blood.
Since the reliability of histamine level detrmination by HPLC is established, these results indicate that the measurement of histamine release in vitro by RIA is sufficiently reliable, simple, and clinically beneficial for young ashmatic children.View full abstractDownload PDF (854K) -
Toshio Shimizu, Toshihiko Hori1990 Volume 4 Issue 2 Pages 178-182
Published: December 25, 1990
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSWe studied the predictive performance of Parameter Estimation and Dosage Adjust (PEDA), a one-compartment Bayesian Patient pharmacokinetic computer program, for the therapeutic drug monitoring (TDM) of theophylline. Twelve asthmatic children (7 of whom are boys), ranging in age from 2 to 9, who received constant aminophylline infusion, were enrolled in this study. The result is that PEDA could well estimate serum theophylline concentratios in asthmatic children, although the accuracy of prediction varied according to the dosing schedule of theophylline. Therefore it is suggested that Bayesian algorithm is useful in TDM of theophylline to asthmatic children.View full abstractDownload PDF (692K)
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