Ampicillin Na (AB-PC) was administered intravenously at a rate of 10 mg/kg/hr for 2 hours to the dogs anesthetized with halothane and enflurane, respectively. The AB-PC concentration reached the maximal values 2hours after the anesthesia (halothane 18.82 μg/ml, enflurane 19.57 μg/ml) which were approximately 1.4 times higher than that of the control dogs (13.84 μg/ml) . In addition, that the lower excretion rate was shown in the anesthetized dogs when terminating the drip infusion of AB-PC may indicate the depression of the excretion during anesthesia. The phenomena mentioned above are considered as the results caused by the deterioration of the blood-tissue permeation. Further study is necessary on the infusion method for maintaining AB-PC concentration during and after the operation.

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A 4-year-old female toy poodle was admitted with signs of unconsciousness, left head tilt, nystagmus of the left eye, paralysis of the limbs and severe salivation due to falling downstairs. Medical therapy including dexamethasone, diazepam administration was started just after the admission, and then radiography and a CT-scan were performed under xylazine sedation. As a result, the left articular process of the occipital bone was fractured and the bone fragment seemed to compress the cervical spinal cord. The patient received the surgery under GOP anesthesia. The ventral aspect of the occipito-atlantal joint was incised and a few bone fragments around the spinal cord were removed. On the 2nd day of postoperation, the light reflex of the both eyes appeared and the patient recovered consciousness on the 3rd day. On the 7th day, the patient showed a good appetite, and anal reflex and postural reflexes of the right forelimb reversed. On the 14th day, the postural reflexes of all the hindlimbs appeared and the patient could show voluntary walking. At the 8th month of postoperation, the gait and other behaviors were almost normal.

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