Clinical and pathological features of 25 canine cutaneous histiocytomas occurring in 24 dogs were reviewed. Major clinical features of these tumors were 5-15 mm in diameter (88%), single lesion (96%), ulceration of the surface (60%), and occurrence on the head or limbs (64%) in less than 5-year-old (88%). Based on the degree of lymphocytic infiltration into the tumor tissues, 20 cases were classified as stages 1 (n=6), 2 (n=8), 3 (n=4), and 4 (n=2). Mitotic indexs in stage 1 or 2 were significantly (p<0.05) higher than those in stage 3 or 4. Neither disease duration nor tumor size was associated with the pathological stage, but the significant relationship between pathological stage and ulceration was observed (p=0.011).

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A 4 years and 6 months and 6 years and 3 months old female rabbits were presented for the abdominal mass with polycythemia. The masses were surgically removed and histopathologically diagnosed as nephroblastoma. This removal resolved polycythemia completely in both cases. One rabbit died one year and 3months after surgery, and another one died 9 months after surgery with unrelated causes in both cases. Blood examination and diagnostic imagings may be valuable for differential diagnosis of the renal tumor in rabbits. In addition, renal tumors shoud be added to a differential diagnosis list when the rabbit with abdominal mass accompanied with polycythemia is presented.

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A 6-year-old Bernese mountain dog was presented with a large subcutaneous mass diagnosed as malignant histiocytosis on the left forelimb. Although the mass and the regional lymph node were surgically resected, the mass recurred in 3 days. Then the orthovoltage radiation (total 36 Gy) and chemotherapy with carboplatin (300 mg/m², 9 times) were conducted over 6 months after the surgery. In 6 months, the mass was completely disappeared without any recurrence and metastasis. However, after the complete remission for over 450 days, the tumor recurrence was observed on 684 days after the first admission, and the left forelimb was amputated due to pathologic fracture. At 850 days after the first admission, pulmonary metastasis was observed, and the owner did not want further treatments. Although this malignant neoplasia is difficult to cure, adjunctive carboplatin administration and radiation may be one of the effective treatments for malignant histiocytosis in Bernese mountain dogs.

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