Usefulness of dobutamine infusion for isoflurane-induced hypotension in 29 thoroughbred racing horses with various diseases was studied. The horses were premedicated with atropine and xylazine. Anesthesia was induced with guanifenesin and thiopental, and maintained with isoflurane. Intermittent positive pressure ventilation was used to avoid hypercapnia. The mean arterial blood pressure was maintained at 70 mmHg during surgery by infusion of dobutamine at a mean dose of 0.30μg/kg/min in lateral recumbency, and 0.66μg/kg/min in dorsal recumbency respectively. A cardiac arrhythmia developed in 2 horses during dobutamine infusion. One horse showed a transient atrial and ventricular premature contraction, and the other showed a junctional premature contraction. All horses recovered uneventfully and postsurgical lameness was not observed.
The sedative and analgesic effects of a new α2 agonist medetomidine in horses were compared with those of xylazine. Five thoroughbred horses were treated on separate occasions with three intravenous doses of medetomidine (10μg/kg, 5μg/kg and 1μg/kg bodyweight) or with one intravenous dose of xylazine (1 mg/kg bodyweight) . Saline (5 ml/horse) was given intravenously as a negative control. Medetomidine at 10μg/kg produced severer and more prolonged sedative effect and ataxia than 1 mg/kg xylazine. Effects of medetomidine at 5μg/kg were similar to that of 1 mg/kg xylazine in duration of sedation less sedation and ataxia were produced. Medetomidine at 1μg/kg produced no sedation and no ataxia. An appropriate dosage of medetomidine for sedation was estimated as at 5μg/kg to 10 μg/kg. Medetomidine is a useful and economical sedative than xylazine in horses.