Adhesion may cause infertility, chronic abdominal and pelvic pain, bowel obstruction, and other significant postsurgical complications. The aim of the study was to assess the preventive effects of trehalose and sodium carboxymethyl cellulose (SCMC) on experimentally induced postsurgical adhesion of internal organs after ovariohysterectomy in a rabbit model. Forty New Zealand white rabbits underwent an ovariohysterectomy in which the visceral organs were desiccated for one hour, either without any protective procedures (control groups A and C) or with trehalose solution (groups B and D) sprayed every 15 min onto the surfaces of the visceral organs. In Group D, the surgical sites were covered by a spray of SCMC and saline solution. The rabbits were sacrificed on postoperative day 14. Adhesion formation and intensity were grossly evaluated and the adhesion tissue was histologically examined. Trehalose tended to decrease the number and severity of adhesions caused by desiccation during surgery between non-operated visceral organ surfaces. The use of SCMC with trehalose decreased adhesion at the sites of surgery (p<0.05). We conclude that trehalose and SCMC together reduce the adhesion of the visceral organs after ovariohysterectomy in the rabbit.

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We applied soft relining materials for denture base, which are used in human dentistry to reduce a pain of putting in a denture, to the two dogs with oral malignant melanoma. Their palates were invaded by tumor and the defects occurred between the oral cavity and the nasal cavity after radiation therapy. Clinical signs of rhinitis such as sneeze were shown when they ate and drunk. The application of relining material to the defects resolved clinical signs and was accepted by each dogs. While regular cleaning or additional applicating to the expanding defects, they lived with good QOL for several months until lung metastasis progressed.

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Two Shih-Tzu dogs were diagnosed as amyloid-producing odontogenic tumor in the maxilla. We concluded the surgical excision difficult, because of their anatomical location. So we treated them with radiotherapy and surgical reduction, but the size of the tumors increased, and caused a decline of quality-of-life. Each of them died after 12 and 16 months from the first medical examination. Amyloid-producing odontogenic tumor is classified as a benign tumor, but its local infiltration is extreme, and showed an aggressive behavior.

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A 8-year-old spayed female, Shih Tzu showed dyspnea caused by intratracheal invasion of thyroid carcinoma and received palliative radiation therapy and a permanent tracheostomy. The protocol of palliative radiotherapy was 9 Gy weekly fractions of orthovoltage X-rays to a total dose of 27 Gy with cisplatin (5 mg/m², iv) in each fraction. Dyspnea improved after the 2nd radiation therapy, but a relapse occurred at 5 months after the treatment. To keep upper airway, a permanent tracheostomy was performed. Following the operation, the dog could have good quality of life for 15 months (20 months after radiation therapy) till pulmonary metastases progressed.

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