Fundamental and clinical studies on AC-1370, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained.
1. The MIC of AC-1370 against Staphylococcus aureus isolated from infectious eye diseases ranged from 12.5-100μg/ml, and MIC of AC-1370 against Klebsiella pneumoniae ranged from 1.56-50μg/ml.
2. Aqueous humor concentration of AC-1370 reached maximum (2.6μg/ml) at 1 hour after an i.v. administration of 50mg/kg in rabbits, and the maximum serum concentration (21.0μg/ml) was obtained at 30 minutes after the injection.
3. High concentration in tear and low concentration in aqueous humor were measured after i.v. administration of 50mg/kg AC-1370 in rabbits.
4. Aqueous humor concentration of AC-1370 in rabbits reached peak at 11 hour after subconjunctival injection 10mg/0.1ml and the peak aqueous humor level was 10.1μg/ml.
5. Two patients with ocular suppurative diseases were successfully treated at a daily dose of 1, 000, 2, 000mg AC-1370. 6, No side effect were observed.
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