To elucidate the pathogenesis of halothane-induced hepatopathy, the changes of hepatic tissue nucleotides and oxypurines were determined in dogs with 1.5% halothane inhalation under the hypoxic condition. Concentrations of adenosine triphosphate and guanosine triphosphate significantly decreased in dogs with halothane inhalation compared to that in the hypoxic condition alone. The concentration of oxypurine, such as hypoxanthine, xanthine, and uric acid, which is accompanied by free radical generation, also increased in dogs with halothane inhalation. These results suggested that free radicals generated from the purine metabolic pathway play an important role on halothaneinduced hepatopathy.

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Five horses were anesthetized with isoflurane for 2 hrs under the intravenous infusion with three different speed of lactated Ringer solution; no administration (control), 10 ml/kg/hr (10 mlgroup) and 40 ml/kg/hr (40 mlgroup) . Hemodynamic responses and hematocrit and serum protein values were measured at 30, 60, 90, 120 min after the beginning of anesthesia. Right atrial pressure and mean pulmonary pressure were unchanged in control, whereas increased gradually in infusion groups. At 60 and 120 min the value of right atrial pressure in 40 mlgroup was significant higher than those of other groups, and mean pulmonary arterial pressure in 40 mlgroup was significantly higher than that of control. Mean arterial pressure and systemic vascular resistance tended to increase, and cardiac output tended to decreased in all the groups in the course of time, however there were no significant differences between the groups in these parameters. Hematocrit and serum total protein levels decreased in infusion groups in the course of time, and those in 40 mlgroup were significantly lower than that of control at 60 to 120 min. At the end of anesthesia, three horses of 40 mlgroup revealed severe edema on their faces. Infusion of lactated Ringer solution was considered as not effective in maintaining blood pressure in anesthetized horse and administration of 40 ml/kg/hr lactated Ringer solution may not be safe.

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A 13-year-old female English Setter with adrenocortical carcinoma was treated with adrenalectomy before onset of hyperadrenocorticism. The grossly visible neoplastic mass including the ipsilateral adrenal gland was completely removed. The contralateral adrenal gland seemed to be normal, however postsurgical hyperkalemia caused from mineral corticoid deficiency appeared and was corrected by predonisolone administration. Ten months after surgery, lung metastasis was radiographically observed and several abnormalities associated with hyperadrenocorticism were detected on both physical and blood examinations. By administration of cisplatin, a transient improvement of the clinical signs and a decrease in plasma cortisol concentration were obtained, however 2 weeks later, the patient died. Necropsy revealed severe metastatic lesions in the lung, spleen, liver, kidney, small intestine, and brain.

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