Part 2. It is discussing quantitatively about the exfoliative tendency of malignant & non-malignant gastric epithelial cells by the proteolytic lavage, depended upon my previous study (part 1). Namely it is considered by the comparrison between the number of exfoliative cells & histological picture in every cases at same dimension of a surface. And these results were obtained.
1) The exfoliative tendency of gastric epithelial cells were variable with it s atrophic degree of glandular epithelial cells and its hyperplastic degree of superficial epithelial cells from benign gastric mucus membrane.
2) There were wide differences between exfoliative tendency of gastric cancer cells in every cases, especially under the influences of proteolytic enzyme lavage. This differences were caused by the cancer cells population, necrotic tendency, patholgicaL type, infiltrative property and secondary infection in every superficial layer of gastric cancer tissue.
Part 3. A. total of 196 symptomatic patients have been examined for gastric malignancy (including 40 gastric cases and 1 gastric reticulum cell sarcoma) by the Trypsirr & Chymotrypsin lavage, depended upon my previous study (part 1.).
And 85% of diagnostic accuracy was obtained. This lavage method is a simple and reliable one to have practical value as one of diagnostic method for gastric malignancy, compared with other methd. But in this diagnostic method it was found that the identification of exfoliated malignant cells and atypical nonmalignant cells were difficult in a few cases. Therefore cellulare pictures in such cases were discussed, comparing cytological and histological findings.

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After the peroral administration of chlorpropamide 2 gm in fasting state, 92% of diabetics exhilited a decline in blood sugar concentration. This effect was significant in such patients in whom duration of the disease and period of insulin treatment were short and requirement for insulin was small. A satisfactory response to 0.125-2 gm of chlorpropamide daily was obtained in 20 of the 27 subjects. In peroral or intravenous glucose tolerance test, no significant improvement was observed after chlorpropamide treatment in such cases in whom fasting blood sugar concentration showed a marked decline.
The impreesion in our observation is that chlorpropamide is definitely more potent than tolbutamide.
Though there were no serious toxic effects, minor side effects were seen in 3 of 31 patieuts. The untoward effects were nausea which did not need the discontinuance the treatment in 2 cases and edema of face in/case after 2 gm administration. There were neither evidence of leucopenia nor of abnormal liver function. It was expected from our observation that chlorpropamide is an effective oral hypogycemic agent in treatment of diabetes.

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One hundred and seventy four liver biopsies were performed in our hospital in the last 8 years.
1. Though there was 4 cases of shock no deaths occured.
2. The cases were as follows: hepatitis 71, liver cirrhosis 39, jaudice of unknown origin 14, liver tumor 9, schistosomiasis japonica 4, Dubin-Johnson's syndrome 1, the other 36.
3. Histologically hepatitis was ciassified as acute severe hepatitis (H₁ type), subacute hepatitis (H₂ type), portal hepatitis (H₃ type), mild hepatitis (H₄ type) and hepatosis (H₅ type). Liver cirrhosis was divided into liver fibrosis (C₁ type), post necrotic cirrhosis (C₂ type), portal cirrhosis (C₃ type), and biliary cirrhosis (BC type). Liver function was damaged most severely in the order of H₁, H₂, H₃, H₄ and H₅ accordingly in cases of hepatitis and in cirrhosis C₂, BC, C₁, C₃ accordingly.
The average dnration from the onset of the disease to discharge from the hospital was H₁ 97 days, H₂ 42 days, H₃ 27 days, H₄ 32 days, C₁ 4 months, C₂ 5 months and C₃ 3 years.
In the follow-up of the 64 cases of hepatitis complaints of subjective symptoms were most in order of H₁, H₂, H₄, H₃ after discharge C₂ had the most complaints among cirrhosis.
Those with severe jaundice histologically were found to have bad prognosis.

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20% of the circulating blood volume was removed in 10 minutes from the gastroepiploic artery or superior mesenteric artery or femoral artery in healthy dogs. We poured the removed blood into the alimentary tract of some of the dogs, and did not with some of them. We observed on the serum N. P. N., the circulating blood volume, the portal tension and the pathologic-anatomic changes of the liver and the kidney from time to time in all of them. In contrast with them, we observed experimentally on the effects of laparotomy. Also we poured some blood of a dog into the alimentary tract of another healthy dog and observed. the effects of it. In many previous reports, they judged alimentary azotemia by the measurement of blood urea nitrogen, but we probed that the judgement of aljmentary azotemia by the measurement of the serum N. P. N. was correct. We observed the slight elevation of the serum N. P. N. in lower intestinal hemorrhage. We thought that absorption of blood, destruction of body protein, and functional renal impairment are the causes of alimentary azotemia. In lower intestinal hemorrgage, as these changes was slight, so the elevation of the serum N. P. N. was slight. The change of circulating blood volume was more evident in the dog which was bled from the gastroepiploic artery. The change in the dog which was bled from the femoral artery was slightest. Hematcrit droped 24 hours after bleeding in all the dogs which were bled. The changes of the serum N. P. N. and C. B. V. were slighter in the dog with which dextran transfusion was carried out immediately after bleeding than in the dog with which it was carried out 12 honrs after bleeding. In the dog which was bled from the gastroepiploic artery, portal tension droped prominently than that was bled from the femoral artery, in company with the hepatic artery circulation. Pathologicanatomic change of the liver was the most prominent in the dog which was bled from the superior mesenteric artery, the slightest was the dog which was bled from the femoral artery. These were coincide with the change of C. B. V. These all recovered 24 hours after bleeding and these were coincide with recovery of C. B. V. We observed phagocytic phenomen of hemosiderin by Kupffers cell in the liver of the dog 96 hours after pouring of blood. We observed collapse of the glomerulus but no other prominent change and we could not observe pathologic-anatomic difference of change by bleeding method.

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