The author was inner pressure of the gallbladder, secretion of the hepatic bile, resistence of the distal end of the common bile duct and tonus of the duodenum simultaneously giving various kinds of solution stated below into the femoral vein of the dog applying the apparatus originally devised at our department.
Those solutions were; two thousand and a hundred times of diluted tuberclin solution, boiled filtrate of the cultured tuberculous bacilli and B. C. G. solution.
The results obtained were as follows.
(1) The gallbladder and the bile duct system were seen to be excited and contracted by giving the injections of two thousand and a hundred times of diluted tuberclin solution, boiled and non boiled filtrates of the cultured tuberculous bacilli into the femoral vein of the dog.
(2) Effects of those solution described in (1) on the gallbladder and bile duct system were similar to that of pilocarpium hydrochloratum and are supposed to act on the same region with pilocarpium hydrochloratum and to act on the mose central region than atropinum sulfuricum and barium chloratum.
(3) Physiological independency of the Oddi's sphincter could not be denied but the cooperation of the duodenum for the distal end resistence of the bile duct was noticed.
(4) No effect of B. C. G. solution on the gallbladder bile duct system was observed.
(5) Hypertonic dyskinesia and hypotonic dyskinesia could bemade artificially from 2 to 4 days later respectively after giving the injection of tuberculin solution into the lumbar musclec of the dog.
(6) The time lag of reaction between the cholecyst and the distal end of the bile duct was noticed.
(7) So-called hypertonic dyskinesia was seen to have lasted far 10 days after the administration of the filtrate of cultured tucerculous bacilli into the lumbar muscles.
With these results mentioned above, an aspect of the relationship between tuberculosisand biliary dyskinesia has been made clear.

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With anesthetized normal dogs, the author has prepared a temporary bileduct-gallbladder-fistula and measured both pressures of bile duct and gallbladder at the same time and then induced the dynamic states of normal bile excretion on Kimographion so that to visualize it. As for the other method the author conducted perfusion of Oddi's sphincter with physiological salt solution and at the same time the movement of duodenum. Thus after injected with cancer-toxin to the dog the change of bile excreting condition were observed.
The results obtained were as follows.
(1) Cancer-toxin which has been extracted from tissue, urine and punctored fluid by Sato's method brought the elevation of gallbladder pressure as well as that of bile duct pressure, and also that brought about a remarkable flow of bile.
(2) In the case of clossing of cystic duct, cancer-toxin brought only the elevation of gallbladder, but brought not a bile flow, so it was considered that cancer-toxin brought a contraction of the gallbladder.
(3) The exciting function of cancer-toxin onethe gallbladder and the bile duct system was approximate to pirocarpin in various autonomic agents, and parasympathetic nature.
(4) A temporary biliary dyskinesia came to pass immediately after the injections of cancer-toxin, but with tne lapse of days was hypertonic dyskinesia.
(5) Cancer-toxin was influenced also for the tonus of the Oddi's sphincter and the motility of the duodenum, that was, brought about a temporary stimulation subsequent to the relaxztion.
(6) Observing the bile excreting conditions under the influence of cancer-toxin which has been extracted from urine and punctured fluid, the author has aquired a hint and devised a original diagnostic method for cancer. It is considered very interesting in its reliability for diagnosis and prognosis of cancer.

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The auther obtained various findings through the detailed experimentation of the influence of various kinds Bacteriotoxins upon the extrahepatic biliary tracts by their orignal experimental methode. Summarized results thereby obtained were as follows:
1. Streptococcus exotoxin stimulated parasympatic nerve for extra hepatic duct, elevated the gall bladder pressure and increased the bile excretion.
2. Ovserving the relation between streptpococcus exotoxin and autonomic nerve poison. The effect of the Streptococcus exotoxin was increased by pilocarpin and decreased by atropin.
3. Streptococcus endotoxin elevated the gall bladder pressure, but afterward took down and the excretion of bile decreased.
4. The endotoxin was simular to adrenalin of autonomic nerve poison.

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The aother experimentaly obtained the relation of the gallbladder pressure, the resistance of the duodenal end of common bile duct and the perfusions quantity of Oddi's sphincter by exotoxin of Streptococcus haemolyticus. The results were as follows:
1. Exotoxin of streptococcus haemolyticus let elevated the gallbladder pressure, accelerated the tensness of duodenal wall, increased resistance of the end of the common bile duct and remarkably decreased perfusions quantity of Oddi's sphincter.
2. Endotoxia of Streptococcus haemolyticus did not show constant tendency.
3. Gallbladder, bile duct and Oddi's sphincter was stimulated by pilocarpin and resistance of the end of common bile duct increased with acceleration of the tenseness of the duodenal wall.
4. By baryum chloratum Oddi's sphincter contracted with acceleration of the tenseness of the duodenal wall, and its perfusions quantity decreased.
5. Atropin remarkably let decreased the resistance of the end of common bile duct, and the perfusions quantity of Oddi's sphincter increased.
6. Influence of acirenalin did not show constant tendency.

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The auther experimented in detail upon the function of Oddi's Sphincter of Streptococcus haemolyticus exotoxin and autonomic nerve poison using which were radially incised their Oddi's sphincter for nompletely cease its function. The results were as follows.
1. Streptococcus exotoxin let elevated pressure of the duodenal end of common bile duct and acceleated tenenss of the duodenal wall will gallbladder pressure, that is the auther confirmed that resistance of the duodenal end of common bile duct was formed by Oddi's sphincter and tenseness of the duoodenal wall.
2. Oddi's sphincter shut at first and afterward Opend by pilocarpin.
3. By barium choloratum the tenseness of the duodenal endof common bile duct was increased.
4. By atropin the tenseness of the duodenal end of common bile duct was decreased.
5. Adrenalin kept under control the tenseness of the duodenal endof common bile duct for a short time.

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