Statistics show that about 60% of young adults and 80% of middleaged people in the United States have periodontal disease, and presumably about the same incidence occurs in Japan. More effective treatment of this affliction is needed. Oral physiotherapy can be ineffective.
There is increasing awareness that good nutrition is related to good periodontal health, and the many known vitamins influence the biochemistry of teeth, periodontium, and related bone. Coenzyme Q
10 (CoQ
10) naturally exists in the mitochondria of gingival tissue and has indispensable functions in the bioenergetics of the gingiva. A significant deficiency (P<0.001) of CoQ
10 in diseased gingival tissues has been repeatedly found.
The clinical administration of three forms of CoQ, CoQ
10, CoQ
7, and hexahydro CoQ
4, has been conducted by general dentists and periodontists with a common conclusion that the administration of this vitamin-like substance was therapeutically beneficial. Six double-blind administrations involving all three forms of CoQ have also been conducted with significant results. The double-blind administration of CoQ
10, the form in human tissue, was significant (P<0.01). Before decoding, all eight patients receiving CoQ
10 and 7/10 patients receiving placebo were correctly assigned.
A study of 29 periodontal patients showed that 100% had a gingival deficiency, and 86% also had a leucocytic deficiency of CoQ
10. The blood deficiency appears to result from nutritional imbalance. A preexisting deficiency of CoQ
10 in the gingiva may predispose this tissue to periodontitis, particularly during neglected oral hygiene. Periodontitis could enhance and also cause a gingival deficiency.
Therapy with CoQ to improve bioenergetics can be effective treatment, and may be used prophylactically or adjunctively for extraordinary healing during routine periodontal therapy.
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