巻号一覧
37 巻, 7 号
選択された号の論文の22件中1～22を表示しています
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TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL PROPERTIESTORU NAGASAWA, HIDEHARU FUKAO, HIROSHI IRIE, HIDEAKI YAMADA1984 年 37 巻 7 号 p. 693-699
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーActinomycete strain M-53, a new soil isolate, was found to produce four quinone-type antibiotics. Antibiotic sakyomicin components A, B, C and D were isolated from the fermentation broth of strain M-53 by XAD-2 column chromatography, silica gel column chromatography and Sephadex LH-20 column chromatography. The components are active against Gram-positive bacteria. Strain M-53 was identified as a strain of genus Nocardia.抄録全体を表示PDF形式でダウンロード (2975K) -
SATOSHI OMURA, HIROSHI MAMADA, NAN-JIN WANG, NOBUTAKA IMAMURA, RUIKO O ...1984 年 37 巻 7 号 p. 700-705
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーA new peptide antibiotic named takaokamycin was isolated from a fermentation broth of Streptomycessp. AC-1978, a soil isolate. It exhibits antibacterial activity against some Grampositive bacteria. The molecular weight was found to be 1, 130 on the basis of elemental analysis, FD-mass spectrum and1H and13C NMR. Acid hydrolysate of takaokamycin contains isoleucine, threonine and unidentified amino acids.抄録全体を表示PDF形式でダウンロード (2308K) -
IWAO UMEZAWA, KANKI KOMIYAMA, HIROFUMI OKA, KENJI OKADA, SHIGERU TOMIS ...1984 年 37 巻 7 号 p. 706-711
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーA new antibiotic kazusamycin, was isolated from the culture broth of Streptomryces sp. No. 81-484, which shows antitumor activity against experimental marine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin suggest that the molecular formula of this antibiotic is C33H48O7 (MW 556).抄録全体を表示PDF形式でダウンロード (2495K) -
I. TAXONOMY OF THE PRODUCER STRAIN AND FERMENTATIONTORU OKUDA, YOSHIO YONEYAMA, AKIKO FUJIWARA, TAMOTSU FURUMAI1984 年 37 巻 7 号 p. 712-717
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーA novel antibiotic, penitricin (Ro 09-0804) was discovered in the culture filtrate of a fungal strain NR 5165. Taxonomic studies of the producing organism resulted in its assignment to Penicillium aculeatum. Further examination on penitricin production by other strains of this species and related taxa revealed that penitricin was produced by several other strains ofP. aculeatum, but not by any available strains of the closely similar species, P. verruculosum. It was also found that copper ion was essential for production of penitricin.抄録全体を表示PDF形式でダウンロード (3192K) -
II. ISOLATION AND CHARACTERIZATIONTORU OKUDA, KAZUTERU YOKOSE, TAMOTSU FURUMAI, HIROMI B. MARUYAMA1984 年 37 巻 7 号 p. 718-722
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーA novel antibiotic, penitricin, Ro 09-0804, has been produced in the culture filtrate of Penicillium aculeatum NR 5165. This antibiotic was purified by repeated extraction of culture filtrate with 1-butanol, and passage of the crude extracts through Sephadex G-10, followed by HPLC (Shodex Ionpak S-801). Physico-chemical characterization was made on penitricin, while two open-ringed penitricins B and C co-produced by the producer strain were also identified.抄録全体を表示PDF形式でダウンロード (1959K) -
III. STRUCTURAL CONFIRMATION BY CHEMICAL SYNTHESIS AND BIOLOGICAL ACTIVITYTORU OKUDA, NOBUO SHIMMA, TAMOTSU FURUMAI1984 年 37 巻 7 号 p. 723-727
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーA novel antibiotic, penitricin showing anti-Gram-negative activity, has been isolated from the culture filtrate of Penicillium aculeatum. Chemical and physico-chemical studies determined the structure of penitricin as hydroxymethylcyclopropenone (1), which was confirmed by chemical synthesis from propargyl alcohol. Biological activity of penitricin and several cyclopropenones as well as two metabolites, penitricins B and C was compared.抄録全体を表示PDF形式でダウンロード (2477K) -
I. FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIESA. K. SAMANTA, S. K. BOSE1984 年 37 巻 7 号 p. 728-732
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーA new antifungal antibiotic, mycoversilin, was isolated from the culture filtrate of Aspergilus versicolor (N5)17 by repeated column chromatography and recrystallized from ethyl acetate as homogeneous fine needles. Maximum production took place in a medium containing 4 glucose and 1% peptone at pH 3.5, temperature 28°C after 8-9 days of incubation under stationary condition. Mycoversilin is a narrow spectrum antibiotic with activity against filamentous fungi, particularly Trichophyton rubrum (MIC 15 μg/ml).抄録全体を表示PDF形式でダウンロード (2138K) -
II. STRUCTURE ELUCIDATIONA. K. SAMANTA, S. K. BOSE, S. B. MAHATO1984 年 37 巻 7 号 p. 733-737
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーThe structure of a new antifungal antibiotic, mycoversilin, produced by Aspergillus versicolor (N5SZ)17 was determined as I by various spectroscopic and chemical methods. Mycoversilin is a unique polynuclear aromatic compound having two methyl and six hydroxyl groups and two ether linkages. The acetyl derivative prepared was found to have no antifungal property.抄録全体を表示PDF形式でダウンロード (1849K) -
II. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 4'-DEOXY DERIVATIVES OF NEOSPIRAMYCIN I AND THEIR 12-(Z)-ISOMERSHIROSHI SANG, MICHI INOUE, SATOSHI OMURA1984 年 37 巻 7 号 p. 738-749
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリー4'-Deoxy derivatives of neospiramycin I and their 12-(Z)-isomers were synthesized by reductive dechlorination via 4'-epi-chloro derivatives. The 12-(Z)-derivatives were more active against bacteria in vitro than the corresponding 12-(E)-derivatives in spite of their low affinities to ribosomes抄録全体を表示PDF形式でダウンロード (5571K) -
III. SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF 4"-SULFONATES AND 4"-ALKYLETHERS OF SPIRAMYCIN IHIROSHI SANO, TOSHIAKI SUNAZUKA, HARUO TANAKA, KINYA YAMASHITA, RYO OK ...1984 年 37 巻 7 号 p. 750-759
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーAmong the derivatives protected with t-butyldimethylsilylether of spiramycin I, 2'-O-acetylspiramycin I 3, 18-(O-t-butyldimethylsilyl)acetal was found to be a suitable intermediate for 4"-modification of spiramycin I. Seven 4"-sulfonates and four 4"-alkylethers were synthesized, which were more active against bacteria in vitro than spiramycin I. 4"-Substituted derivatives with relatively small sulfonyl and alkyl groups were comparable in therapeutic effect to spiramycin I.抄録全体を表示PDF形式でダウンロード (4656K) -
IV. SYNTHESIS AND IN VITRO AND IN VIVO ACTIVITIES OF 3", 4"-DIACYLATES AND 3, 3", 4"-TRIACYLATES OF SPIRAMYCIN IHIROSHI SANO, TOSHIAKI SUNAZUKA, HARUO TANAKA, KINYA YAMASHITA, RYO OK ...1984 年 37 巻 7 号 p. 760-772
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリー3", 4"-Diacylates and 3, 3", 4"-triacylates of spiramycin I were synthesized and evaluated by the four parameters, MIC against bacteria, affinity to ribosomes, retention time in HPLC and therapeutic effect. Among them, 3, 3", 4"-tri-O-propionyl and 3, 4"-di-O-acetyl-3"-O-butyrylspiramycin I were the most active in viro, which were superior to acetylspiramycin.抄録全体を表示PDF形式でダウンロード (5043K) -
PUSHPA D. SINGH, MARIAN G. YOUNG, JANICE H. JOHNSON, CHRISTOPHER M. CI ...1984 年 37 巻 7 号 p. 773-780
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーTwo new 7-formamidocephalosporins have been isolated as their acetyl derivatives (SQ 28, 516 and SQ 28, 517) from fermentations of a Flavobacterium sp. SC 12, 154. Structure 1 was deduced for SQ 28, 516 from its spectroscopic properties while structure 2 was proposed for SQ 28, 517. SQ 28, 516 exhibits weak antibacterial activity.抄録全体を表示PDF形式でダウンロード (3805K) -
GLORIA REVILLA, MANUEL J. LóPEZ-NIETO, JOSE M. LUENGO, JUAN F. ...1984 年 37 巻 7 号 p. 781-789
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーThe addition of glucose to batch cultures of Penicillium chrysogenumNA AS-P-78 reduced the biosynthesis of penicillin. This regulatory effect was also observed in penicillin biosynthesis by nitrogen-limited resting cells when cultures were previously grown in high concentrations of glucose. The effect of glucose was concentration-dependent in the range of 28-140 mM. Incorporation of L-[U-14C]valine into penicillin in nitrogen-limited resting cultures was reduced by 70% when cells were grown on 140 mm glucose, as compared with that grown on lactose. It was not affected when the sugar was added to the resting cell system, in which penicillin biosynthesis took place without growth. Fructose, galactose and sucrose exerted the regulatory effect to the same extent as glucose (64 to 70%). Lactose did not exert suppression of penicillin biosynthesis. Penicillin-synthesizing activity in control cultures with lactose reached a peak at 24 hours of incubation and decreased slowly thereafter, as studied with resting cell cultures in which further protein synthesis was blocked with cycloheximide. Glucose repressed the formation of penicillin-synthesizing enzymes, but had no effect on the activity of these enzymes. These results suggest that glucose represses but does not inhibit penicillin biosynthesis.抄録全体を表示PDF形式でダウンロード (4578K) -
YASUTAKA SHIGI, YOSHIMI MATSUMOTO, MAMIKO KAIZU, YOKO FUJISHITA, HITOS ...1984 年 37 巻 7 号 p. 790-796
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーThe mechanism of action of a new orally active cephalosporin, FK027, was compared to that of cephalexin and cefaclor to elucidate its excellent antibacterial activity against Gram-negative bacteria. FK027 showed very high affinity for the penicillin-binding proteins (PBPs) 3, 1a and 1bs of Escherichia coli whereas cephalexin showed fairly high affinity for PBPs 1a, 4 and 3. The ability of FK027 to penetrate the outer membranes of E. coli and Enterobacter cloacae was less than that of cephalexin and cefaclor. However, FK027 was extremely stable to both plasmid-mediated penicillinases and chromosomal β-lactamases except theBacteroides fragilis enzyme and its stability was superior to that of cephalexin and cefaclor. These results indicate that the potent antibacterial activity of FK027 is based on its enhanced affinity for the target enzymes and its high stability to β-lactamases.抄録全体を表示PDF形式でダウンロード (3995K) -
PETER H. CALCOTT, RAYMOND O. III FATIG1984 年 37 巻 7 号 p. 797-801
発行日: 1984年
公開日: 2006/04/19
ジャーナル フリーHigh affinity [3H]GABA (γ-aminobutyric acid) binding sensitive to muscimol and bicuculline was detected in membranes derived from rat brain and brine shrimp. Avermectin stimulated this GABA binding with maximum stimulation seen in these membranes at 400 and 40-80 ng/ml, respectively. This avermectin stimulation of GABA binding was Cl--dependent, bicuculline and picrotoxin-sensitive and was associated with an increase in Bm but not Kd of the systems. The membranes from Mucor miehei also exhibited high affinity [3H]GABA binding that was insensitive to classical neuronal GABA receptor agonists/antagonists and other agents. This novel GABA receptor was sensitive to Na+ and extremely sensitive to low levels of avermectin (apparent Ki 20-40 ng/ml). This inhibition of GABA binding by avermectin was associated with a decrease in affinity (increase in Kd) and an increase in concentration of receptors (Bm). It is possible that these GABA receptors might play crucial roles in control of cell metabolism and that avermectin can prevent growth of this organism via interference in the receptor activity.抄録全体を表示PDF形式でダウンロード (2655K) -
TAXONOMY, FERMENTATION AND BIOLOGICAL PROPERTIESJ. SCOTT WELLS, WILLIAM H. TREJO, PACIFICO A. PRINCIPE, RICHARD B. SYK ...1984 年 37 巻 7 号 p. 802-803
発行日: 1984年
公開日: 2006/04/19
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JOSEPH O'SULLIVAN, CAROL A. AKLONIS1984 年 37 巻 7 号 p. 804-806
発行日: 1984年
公開日: 2006/04/19
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ROGER LABIA, JEAN-MICHEL MASSON, PASCALE BARON1984 年 37 巻 7 号 p. 807-808
発行日: 1984年
公開日: 2006/04/19
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A COMPARATIVE STUDYPIERRE MARCHE, ARLETTE GIRARD1984 年 37 巻 7 号 p. 809-812
発行日: 1984年
公開日: 2006/04/19
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JOHN W. WESTLEY, CHAO-MIN LIU, LILIAN H. SELLO, NELSON TROUPE, JOHN F. ...1984 年 37 巻 7 号 p. 813-815
発行日: 1984年
公開日: 2006/04/19
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VI. THE X-RAY CRYSTAL STRUCTURE INVESTIGATION OF PENTALENOLACTONE G AND STRUCTURAL REVISION OF PENTALENOLACTONE FHARUO SETO, HIROSHI NOGUCHI, USHIO SANKAWA, YOICHI IITAKA1984 年 37 巻 7 号 p. 816-817
発行日: 1984年
公開日: 2006/04/19
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BIRENDRA N. PRAMANIK, ALAN K. MALLAMS, P. L. BARTNER, R. R. ROSSMAN, J ...1984 年 37 巻 7 号 p. 818-821
発行日: 1984年
公開日: 2006/04/19
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