About 3000 microorganisms (bacteria,
Actinomyces,
Zygomyces,
Deuteromyces) were screened for their capacity to convert mevinolin.
Absidia coerulea IDR 705 was found to produce two hydroxylated derivatives of mevinolin,
2 and
3. Compound
2 is a new transformation product while compound
3 was described as a chemical modification product of mevinolin
1). By combination of spectroscopic techniques, the structures of
2 and
3 were identified with β, δ-dihydroxy-7-(l, 2-dihydro2-hydroxymethyl-6-methyl-naphthalen-l-yl)-heptanoic acid δ-lactone and β, δ-dihydroxy-7-[1, 2, 3, 5, 6, 7, 8, 8a-octahydro-3, 5-dihydroxy-2, 6-dimethyl-δ-(2-methyl-butyryloxy)-naphthalen-l-yl]heptanoic acid δ-lactone, respectively. The inhibitory effects of the two derivatives on the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase were similar to that of mevinolin.
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