Two new benzofurans, 5, 6-dihydroxybenzofuran-2, 3-dicarboxylic acid dimethyl ester (kynapcin-13) and 5, 6, 5', 6'-tetrahydroxy[3, 3']bibenzofuranyl-2, 2'-dicarboxylic acid 2'-methyl ester (kynapcin-28) were isolated from
Polyozellus multiplex, and shown to non-competitively inhibit prolyl endopeptidase (PEP), with the IC
50 values of 76.80 and 0.98μM, respectively. Kynapcin-13 and -28 were less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.
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