¹⁸F-Fluorodeoxyglucose positron emission tomography has become an important informative modality during the past two decades. Because this type of tomography is a functional imaging construct, its primary use is in the field of oncology. It is being used increasingly in the management of several tumor types including esophageal cancer. These tomography scans can distinguish between benign and malignant tumors, identify stages of tumor spread, assess tumor recurrence, and monitor the response of malignant disease to therapy. The aim of this review was to outline the current and future roles of positron emission tomography in the management of esophageal cancer.

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Radical treatment for achalasia is currently unavailable. At present, most palliative procedures are designed improve the passage of food through the gastroesophageal junction and thereby alleviate symptoms. Drug therapy is of limited, transient effectiveness. Pneumatic dilation (PD) is considered superior to endoscopic botulinum toxin injection (EBTI). The mainstay of surgical treatment for achalasia is laparoscopic Heller myotomy (LHM) with fundoplication, currently considered superior to PD. Per oral endoscopic myotomy (POEM), a “state-of-the-art” procedure for minimally invasive surgery, holds great promise for the future management of achalasia. Definitive conclusions regarding the benefits and risks of currently available treatments for achalasia must await the accumulation of evidence from well-designed clinical trials.

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Purpose: to evaluate the efficacy and safety of intrapleural analgesia (IPA) using ropivacaine after thoracoscopic surgery, compared with thoracic epidural analgesia (TEA) using ropivacaine.
Methods: forty patients undergoing thoracoscopic bullectomy for spontaneous pneumothorax were randomly assigned to one of two groups. IPA group (n = 20) received intermittent bolus injection of 0.375% ropivacaine into intrapleural space two times; at the end of operation and one more time as the pain increased. TEA group (n = 20) received continuous epidural analgesia with 0.375% ropivacaine. Transrectal diclofenac was administered as an additional analgesic. Pain was assessed on the basis of additional analgesics requirements and by using a visual analog scale (VAS).
Results: the time courses of VAS scores along the postoperative time course were not significantly different (p = 0.175). Consumption of transrectal diclofenac was significantly smaller in IPA group (p = 0.025). No major complications appeared in both groups, and incidence of adverse symptoms was not different.
Conclusions: in IPA group, pain was managed with less consumption of additional analgesics. IPA could be one of the good choices after thoracoscopic surgery for its efficacy, safety, and benefit of easy placement of the catheter.

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Purpose: We have reconstructed aortic valves using autologous pericardium treated with glutaraldehyde since April 2007. However, the strength of the human pericardium has not been confirmed. We compared tensile strength between glutaraldehyde-treated human pericardium and aortic valve leaflets with various degrees of calcification to determine their suitability for use in aortic valve reconstruction.
Methods: We measured the ultimate tensile strength and elasticity of samples of glutaraldehyde-treated pericardia (n = 8), non-calcified (n = 12), calcified (n = 9) and decalcified (n = 21) aortic leaflets collected from 23 patients who underwent aortic valve surgery. Aortic valves were decalcified using a cavitational ultrasonic surgical aspirator. The pericardium was immersed in 0.6% buffered glutaraldehyde for 10 minutes and then rinsed three times for 6 minutes each in normal saline.
Results: The ultimate tensile strength of the glutaraldehyde-treated human pericardium, non-calcified, calcified and decalcified leaflets was 10, 2.8, 1.0 and 0.8 MPa, respectively.
Conclusions: The ultimate tensile strength of glutaraldehyde-treated human pericardium was 4 times higher than non-calcified leaflets, indicating its suitability for application to aortic valve reconstruction. Calcified leaflets were slightly stronger than decalcified leaflets. Thus, calcification can be removed without altering the tensile strength of valve materials.

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Introduction: The purpose of this study is to know the influence of coronary artery bypass grafting (CABG) on coronary circulation. In the present study, we evaluated CABG by using a novel flow analyzer that can calculate bypass graft resistance (Ra), resistance of the peripheral bed to which graft connects (Rp), the inertia of blood flow through the graft (L) and vascular wall compliance (C).
Methods: We performed off-pump CABG surgery on fifteen pigs assigned to the following groups (n = 5 each): normal CABG, competitive flow grafts and constrictive grafts.
Results: The wave pattern of 3 groups showed a clearly different form. In normal CABG and competitive flow group, we accepted a statistical difference in Rp and flow. In normal CABG and constrictive grafts. We accepted a statistical difference in Ra and flow.
Conclusion: We can know the relationship between CABG and coronary circulation by this device in detail. This device will be useful for evaluating graft performance during CABG.

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Subjects: Currently, hemostatic materials made from human blood components and animal-derived collagen is used for controlling operative hemorrhage in the cardiovascular surgery field. In this study, we focused on an entirely synthetic self-assembling peptide (development code: TDM-621) that gels when in contact with blood or other bodily fluids and stops bleeding upon contact with a wound site. We investigated its usefulness as a hemostatic material in animal and clinical studies.
Methods: Before we began the clinical study, we demonstrated the hemostasis efficacy and safety of TDM-621 in animal experimental models. Twenty-five patients (22 men, 3 women) were enrolled in the clinical study, and the following procedures were performed: 1) coronary artery bypass graft (CABG) (n = 9), 2) abdominal aortic graft replacement (n = 4), and 3) peripheral artery bypass (n = 12). The TDM-621 material was applied to a total of 33 vascular anastomotic graft sites (some patients received material at more than one site). Both hemostatic efficacy and safety were examined.
Results: A total of 33 anastomotic graft sites in 25 patients were evaluated, and the averaged primary and secondary efficacy rate was 94.5%. No postoperative bleeding or adverse events (including serious adverse events) with a causal relationship to treatment were observed.
Conclusion: This study indicated that TDM-621 is a more effective and reliable hemostat than commonly-used general hemostatic agents and, therefore, will be very useful in several cardiovascular surgery applications.

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Objectives: Chronic heart failure after myocardial infarction is still a serious problem without a fundamental therapy. Direct intramyocardial transplantation of bone marrow cells (BMC) is promising but difficult to perform. Therefore, cardiac effect of experimental intravenous application of BMC after myocardial infarction (MI) is evaluated.
Methods: 20 Lewis rats underwent suture ligation of the LAD. One month after the MI, they were randomized to receive either intravenous Lewis-BMC or saline injection. Hearts were explanted and histologically examined another month later. Transthoracic echocardiography was performed before MI and intravenous injection as well as before explantation.
Results: BMC transplanted animals developed less cartilaginous metaplasia (BMC-group: 30% vs Control-group: 50%, p <0.01). Moreover, systolic thickness of the interventricular septum (IVSs) increased significantly in the BMC-group only: pre-Tx 1.4 ± 0.5 mm vs post-Tx 2.3 ± 0.5 mm, p = 0.02; whereas, systolic left ventricular posterior wall diameter (LVPWD) increased in the control groups only: pre-Tx 2.6 ± 0.5 mm vs post-Tx 3.4 ± 0.8 mm, p = 0.04. BMC transplantation showed a tendency towards a smaller infarct area (BMC group, 11% vs. Control group, 13%; p = 0.07) and increases in LVEF and FS after an intravenous injection (p = 0.08).
Conclusion: Intravenous BMC-Tx led to less calcifying remodelling and a compensatory hypertrophy within the infarction area that probably contributes to functional recovery.

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The operative indications for rib fracture repair have been a matter of debate. However, several reports have suggested that flail chest, pain on respiration, and chest deformity/defect are potential conditions for rib fracture repair. We describe our experience of rib fixation in a patient with severe chest deformity due to multiple rib fractures.
A 70-year-old woman was admitted with right-sided multiple rib fractures (2nd to 7th) and marked chest wall deformity without flailing caused by an automobile accident. Collapse of the chest wall was observed along the middle anterior axillary line. At 11 days after the injury, surgery was performed to repair the chest deformity, as it was considered to pose a risk of restrictive impairment of pulmonary function or chronic intercostal pain in the future.
Operative findings revealed marked displacement of the superior 4 ribs, from the 2nd to the 5th, and collapse of the osseous chest wall towards the thoracic cavity. After exposure of the fracture regions, ribs fixations were performed using rib staplers. The total operation time was 90 minutes, and the collapsed portion of the chest wall along the middle anterior axillary line was reconstructed successfully.

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Treatment strategies for synchronous, multiple peripheral lung cancers remain controversial. Bilobectomy for multiple lung cancers could cause pulmonary function impairment. We report two patients with synchronous multiple peripheral non-small cell lung cancers, who underwent multiple segmentectomy simultaneously. This is the first report of consecutive segmentectomy of two segments.

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A 31-year old female with anorexia nervosa was referred to the Department of General Surgical Science at Gunma University for a surgical resection of a pulmonary aspergilloma. The patient had received treatment for anorexia nervosa at the Department of Psychiatry of the Hospital of Gunma University Graduate School of Medicine. A chest radiograph showed an infiltrative shadow with apical pleural thickening in the left upper lung field. A contrast enhanced computed tomography showed an irregular mass shadow with cavity formation that involved spherical clusters in the left upper lobe. The patient was diagnosed with pulmonary aspergilloma by serological studies and radiological features. A pulmonary segmentectomy of the left apical segment (S1 + 2) through a lateral thoracotomy was successfully performed. She had an uneventful postoperative recovery, and the final histopathological examination confirmed the diagnosis of pulmonary aspergilloma. This is a rare case study of a young female patient with anorexia nervosa who developed pulmonary aspergilloma.

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Here, we report a rare case of a 39-year-old male who presented with left forearm pain and swelling as the initial manifestation of non-small cell lung cancer (NSCLC). The patient underwent chemoradiotherapy followed by surgical resection of the primary lesion as a salvage treatment. Four years and 7 months after his first presentation, the patient is alive with no symptoms of recurrence or metastasis. Although the optimal treatment for skeletal muscle metastasis from NSCLC has not been determined, aggressive treatment for the primary and the solitary metastatic lesion could be considered as a potentially successful treatment option.

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We describe the successful treatment of pulmonary aspergilloma by limited thoracoplasty used simultaneously with single-stage cavernostomy and a muscle transposition flap. An 80-year-old man with dyspnea on effort and hemoptysis consulted our hospital. Chest computed tomography revealed a thick wall cavity containing a fungus ball surrounded by a crescent of air and diseased lung parenchyma, indicating complex pulmonary aspergilloma (CPA). As curative pulmonary resection was considered too invasive for this patient, limited thoracoplasty with simultaneous single-stage cavernostomy and myoplasty was performed as an alternative treatment. During the operation, transposition flap of the latissimus dorsi muscle was created by preserving the feeding artery. Fungus, in the ball that was removed, proved to be aspergilloma by culture and histopathological examination. On postoperative day 15, the patient was discharged uneventfully, and 4 months after surgery, no relapse of the aspergilloma has been observed.
We consider that limited thoracoplasty with simultaneous single-stage cavernostomy and a muscle transposition flap is effective for treatment of high-risk CPA.

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Cardiovascular surgery in the setting of chest wall deformities is a clinical challenge. Pectus excavatum, for example, can cause heart displacement to the left thoracic cavity, following the poor operative field. This report highlights a case in which a successful aortic valve-sparing operation via conventional median sternotomy after correction of the heart displacement due to pectus excavatum using Nuss procedure in Marfan syndrome. This technique can be one surgical option in Marfan syndrome patients with pectus excavatum and thoracic aortic aneurysm under close follow up.

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A 69-year-old man was transferred to our hospital because of sudden onset precordial pain and dyspnea. Transesophageal echocardiography revealed massive aortic regurgitation, diastolic separation of the closure line of the aortic cusps and prolapsing motion of the cusps during diastolic toward the left ventricular outflow tract. Aortic valve replacement was successfully performed. During the operation, we found a commissure between the left coronary cusp and the non-coronary cusp that had avulsed from the aortic wall and prolapsed into the left ventricular outflow tract. Valvular cusps were excised and replaced with a mechanical prosthesis. The postoperative course was uneventful and the patient was discharged from the hospital, 25 days after his operation. The histopathological examination showed fibrosis, hyalinosis of the avulsed commissure, and mucoid degeneration of the valve. There was no evidence of pathologic changes, such as aortitis, infective endocarditis, or specific connective tissue disorders.

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Presented is a case of a young, polytoxicomaniac male with a history of intravenous drug abuse. He arrived at our department in a septic state with fever and showed signs of right-sided decompensated cardiac insufficiency. The patient tested positive for hepatitis C, and blood cultures were positive for Staphylococcus aureus. A thoracic computed tomographic scan revealed bilateral, multiple septic pulmonary emboli. Transesophageal echocardiography disclosed large mobile vegetations on the tricuspid valve associated with severe regurgitation. The infected tricuspid valve was replaced with a mechanical heart valve, and the patient recovered uneventfully from surgery.

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An 82-year-old woman, who underwent axillo-bifemoral bypass for infrarenal aortic occlusion and peripheral arterial occlusive disease 9 years before, was admitted to our hospital for swelling in the left subclavicular region. Ultrasound examination revealed a leak in the wall of the bypass graft with the formation of a false aneurysm. No signs of infection, either locally or systemically, were observed. Resection of the aneurismal segment with interposition using a Dacron graft was performed. Macroscopic findings during surgery confirmed an intact anastomotic region of the left axillary artery and Dacron graft. Two possible mechanisms for the formation of this false aneurysm, either cumulative stress on the graft over the years or Dacron graft biodegradation, were hypothesized.

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Cerebrospinal fluid (CSF) drainage is a routinely used adjunct in operation of thoracoabdominal aortic aneurysm (TAAA), which may reduce the incidence of perioperative paraplegia by improving spinal cord perfusion. Neurological complications of CSF drainage have been reported, possibly due to excessive CSF drainage, and acute subdural hematoma (SDH) in particular may lead to catastrophic complications. We present a rare case of acute SDH due to CSF drainage that was not excessive, after TAAA repair in a patient with Marfan syndrome, who recovered without invasive treatment.

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Pulmonary artery aneurysm (PAA) is generally a rare lesion, and there is no definitive approach for it. We report the case of a 45-year-old man who was admitted for the evaluation of dyspnea. In childhood, he had been diagnosed with PAA with congenital pulmonary valve stenosis and regurgitation, and he had a percutaneous transvenous pulmonary valve commissurotomy. Transthoracic echocardiogram showed dilatation of the right atrium and right ventricle, with right ventricular hypertrophy. There was severe pulmonary valve regurgitation, and the main pulmonary artery was dilated to 68 mm in diameter. From the surgical findings, the left leaflet of pulmonary valve was torn from commissure with failure to coapt with the other leaflet. After direct sutures of edges of the left leaflet, a nearly normal valvular competence was restored. The PAA was repaired with a Y-shaped 24 × 12 mm Dacron graft replacement. The postoperative course was uneventful, and the patient was discharged.

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