Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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Volume 42, Issue 2
Issue 240
Displaying 1-9 of 9 articles from this issue
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Perspective
Overview
  • Molecular Recognition of Calmodulin in the Absence of Ca2+
    Yoshinobu IZUMI
    Article type: scientific monograph
    Subject area: Infomation Science
    2002 Volume 42 Issue 2 Pages 60-65
    Published: 2002
    Released on J-STAGE: April 09, 2002
    DOIhttps://doi.org/10.2142/biophys.42.60
    JOURNAL FREE ACCESS
    Supplementary material
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    Ca2+-free calmodulin (apocalmodulin) binds target proteins and alters their function. Apocalmodulin has roles in the cell that apparently do not require the ability to bind Ca2+ at all, and these roles appear to be essential for cell's metabolism. Small-angle X-ray scattering (SAXS) results indicate that the overall conformation of apocalmodulin remains unchanged, but the conformation for the C-domain changes from the closed to semi-open conformation upon binding the target proteins. The conformational change would be induced by electrostatic interactions and subsequent van der Waals interactions and it can cause changes in the Ca2+ affinity of the apocalmodulin-target protein complex. An analysis of residue pairs between calmodulin and target peptides suggests that apocalmodulin recognizes Ca2+-dependent calmodulin binding proteins, utilizing a new motif different from IQ motif.
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Review
  • Structure-Function Relationship of Flavoproteins
    Kazuko YORITA
    Article type: scientific monograph
    Subject area: Infomation Science
    2002 Volume 42 Issue 2 Pages 66-71
    Published: 2002
    Released on J-STAGE: April 09, 2002
    DOIhttps://doi.org/10.2142/biophys.42.66
    JOURNAL FREE ACCESS
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    Flavoproteins are involved in many different biological events from biological oxidations to apoptosis. This versatility might come from cross talk between the flavin molecule and amino acid residues in the active site. Physicochemical approaches on the relationship between structure and function of the flavin and the protein in L-lactate oxidase are reported here to solve the common reaction mechanism of enzymes of the α-hydroxy-acid oxidase family.
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Topics
Experimental techniques
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