Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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Volume 62, Issue 5
Issue 363
Displaying 1-17 of 17 articles from this issue
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Perspective
Review
  • De Novo Design of a Nanopore for Single-molecule Detection that Incorporates a β-hairpin Peptide
    Keisuke SHIMIZU, Masataka USAMI, Ikuro MIZOGUCHI, Shoko FUJITA, Ryuji ...
    2022 Volume 62 Issue 5 Pages 271-275
    Published: 2022
    Released on J-STAGE: November 25, 2022
    DOIhttps://doi.org/10.2142/biophys.62.271
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    De novo protein design has emerged as a method to manipulate the primary structure for the development of artificial proteins and peptides with desired functionality. This paper describes the de novo design of a pore-forming peptide that has a β-hairpin structure and assembles to form a stable nanopore in a bilayer lipid membrane. We designed two kinds of peptides, SV28: forming multidispersely-sized nanopore and SVG28: monodispersely-sized nanopore, and succeeded to detect single molecule DNAs and polypeptides. Such de novo design of a β-hairpin peptide has the potential to create artificial nanopores, which can be adjust size to a target molecule.

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  • Information Efficiency in E. coli Chemotaxis
    Keita KAMINO
    2022 Volume 62 Issue 5 Pages 276-279
    Published: 2022
    Released on J-STAGE: November 25, 2022
    DOIhttps://doi.org/10.2142/biophys.62.276
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    Organisms acquire and use sensory information to guide their behaviors. However, it is unclear whether and how this information constrains the ability of organisms to perform behavioral tasks. In a recent work, using E. coli chemotaxis as a model system, we showed that the sensory information that a bacterium acquires sets an upper limit on its behavioral performance. Furthermore, combined with quantitative experiments, we quantified the rate at which E. coli acquire information during navigation and discovered that E. coli use the acquired information efficiently. Here, we succinctly review the key findings of the work.

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  • Intracellular Size Scaling of Cell Nucleus
    Yuki HARA
    2022 Volume 62 Issue 5 Pages 280-284
    Published: 2022
    Released on J-STAGE: November 25, 2022
    DOIhttps://doi.org/10.2142/biophys.62.280
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    The eukaryotic cells can change the size of the cell nucleus, including the genomic DNA, depending on the environment surrounding the cell nucleus. How cells can scale the nuclear size by sensing the environment has remained an enigma for over a century in the field of cell biology. Here, we found a general scaling rule of nuclear size to cell size among eukaryotes and another new aspect for size scaling to the chromatin status inside the nucleus. In this review, I describe the known mechanisms underlying these size scaling characteristics and discuss putative physiological significances for the size scaling.

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Topics (Young Scientist Series)
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Activity of Regional Branch
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Letters from Abroad
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