Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
Volume 47, Issue 6
Issue 274
Displaying 1-17 of 17 articles from this issue
Perspective
Feature Articles
Review
  • Takahide KON
    2007 Volume 47 Issue 6 Pages 384-389
    Published: 2007
    Released on J-STAGE: November 30, 2007
    JOURNAL FREE ACCESS
    Dynein is an AAA+ type motor complex that utilizes ATP hydrolysis to move toward the minus end of microtubules. Mechanistic studies on dynein have been hampered by its enormous size (a molecular mass of > 1 MDa) and molecular complexity. However, recent advances in structural and functional studies, including electron microscopic observations and mutational analyses along with establishment of recombinant expression systems, are now beginning to shed light on the molecular mechanism of dynein. Here, I summarize these recent studies, focusing on the coupling between ATP hydrolysis cycle and conformational changes that is critical for the dynein-based motility.
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  • Yoshinori TAMAI
    2007 Volume 47 Issue 6 Pages 390-396
    Published: 2007
    Released on J-STAGE: November 30, 2007
    JOURNAL FREE ACCESS
    Applications of molecular simulation in the field of polymer physical chemistry are presented in terms of crystallization, interaction to small molecules, and hydration. Full atomistic models are suitable for investigating these phenomena since atomistic interaction plays important roles. From a different point of view, these studies in the field of polymer science lead to fundamental understandings of various biophysical problems, such as physical chemistry of amyloid fibrils, which may cause neurodegenerative diseases.
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Salon
Activity of Regional Branch
Young Voice
International Trend in Biophysics
Promenade along Protein 3D Structures
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