Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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Volume 63, Issue 6
Issue 370
Displaying 1-15 of 15 articles from this issue
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Perspective
Review
  • Dynamics of the Spontaneous Nucleation of Microtubules
    Hiroshi IMAI, Etsuko MUTO
    2023 Volume 63 Issue 6 Pages 299-302
    Published: 2023
    Released on J-STAGE: January 25, 2024
    DOIhttps://doi.org/10.2142/biophys.63.299
    JOURNAL FREE ACCESS FULL-TEXT HTML
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    The structural pathway of spontaneous microtubule nucleation was identified for the first time using recombinant mutant tubulin with a high nucleation rate, rapid flash-negative stain electron microscopy, and kinetic analyses of the size of critical nucleus. The single-stranded tubulin oligomers assembled during the early stage of polymerization had a variety of lengths and curvatures; however, the majority of these oligomers dissociated to tubulin. It was the few straight oligomers exceeding the critical size that underwent lateral interaction, had two-dimensional growth into sheets, and eventually closed into microtubules.

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Topics
Theoretical and experimental techniques
Salon
Activity of Regional Branch
Young Voice
Letters from Abroad
Technical term
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