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Volume 45, Issue 4
Issue 260
Displaying 1-12 of 12 articles from this issue
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Perspective
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Yoko TOYOSHIMA2005Volume 45Issue 4 Pages 175
Published: 2005
Released on J-STAGE: July 25, 2005
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Overview
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Futoshi TAURA, Yoshinari SHOYAMA, Satoshi MORIMOTO2005Volume 45Issue 4 Pages 178-184
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESSCannabis sativa produces novel secondary metabolites called cannabinoids. Among them, Δ1-tetrahydrocannabinol (THC), the psychoactive component of this plant, has attracted a great deal of attention, because this cannabinoid is shown to exert a variety of therapeutic activities such as the relief of nausea caused by cancer chemotherapy. To reveal the mechanism of THC formation in Cannabis sativa, we attempted biosynthetic studies. Consequently, we established that Δ1-tetrahydrocannabinolic acid (THCA), the precursor of THC, is derived from cannabigerolic acid and that this reaction is catalyzed by the novel oxidocyclase, THCA synthase. Here, we show the biochemical and structural properties of THCA synthase.
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Shizufumi EBIHARA, Shinobu YASUO, Takashi YOSHIMURA2005Volume 45Issue 4 Pages 185-191
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESSAlthough photoperiodic response has been an object of study for a long time, little is known about molecular mechanisms underlying this phenomenon. Recently, we have identified the gene (Dio2) which regulates photoperiodic response in gonadal growth in birds and possibly in mammals. Prolactin secretion is also regulated by photoperiod. However, the mechanisms of this response are different from those of gonadal response. Here, we overview current knowledge about vertebrate photoperiodic response, providing our recent results on molecular studies.
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Review
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Kenji IWASAKI, Atsuo MIYAZAWA2005Volume 45Issue 4 Pages 192-197
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESSA hybrid approach using X-ray crystallography and cryo-electron microscopy provides opportunities to reveal the activation mechanism and pathway of biological macromolecules with large conformational changes. Structural analysis of the Ca2+ release channel, inositol 1,4,5-trisphosphate receptor (IP3R) is a good example to introduce this powerful approach. Docking of the atomic coordinate of the fragment including binding domain of inositol 1,4,5-trisphosphate (IP3) and Ca2+ into the three-dimensional density map of the type 1 IP3R reconstructed from cryo-electron micrographs leads to proposing a novel regulation mechanism of Ca2+ mobilization.
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Hiroto OGAWA, Kotaro OKA2005Volume 45Issue 4 Pages 198-202
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESSWe examined dendritic activity in identified mechanosensory interneurons in the cricket cercal sensory system using Ca2+ imaging and intracellular recording techniques. Different dendritic branches of the interneurons displayed distinct directional sensitivity profiles to air-current stimuli. The amplitude of evoked spikes was larger at the dendritic branches in which the Ca2+ elevation was larger. Dual-site recordings of the dendritic spikes indicate that the spike-initiation site shifts depending on the location of the site of synaptic activation. We propose that a difference in spike-propagation direction could change the spike waveform at the distal dendrite and could produce synaptic activity-dependent Ca2+ dynamics.
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Topics
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Nobutada TANAKA2005Volume 45Issue 4 Pages 203-206
Published: 2005
Released on J-STAGE: July 25, 2005
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Theoretical and experimental techniques
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Shun HIROTA2005Volume 45Issue 4 Pages 207-210
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESS
Supplementary materialDownload PDF (601K) -
Noriyuki HAMA, Masakazu TAKAHATA, Yoshikazu TSUCHIDA2005Volume 45Issue 4 Pages 211-215
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESS
Supplementary materialDownload PDF (579K)
Tips and Hints
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Kazuhiko KINOSITA, Jr., Katsuyuki SHIROGUCHI, Tetsuaki OKAMOTO, Kengo ...2005Volume 45Issue 4 Pages 216-218
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESSDownload PDF (261K)
Salon
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Yuki KUNIOKA2005Volume 45Issue 4 Pages 219-223
Published: 2005
Released on J-STAGE: July 25, 2005
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Technical term
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2005Volume 45Issue 4 Pages 191
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESSDownload PDF (53K) -
2005Volume 45Issue 4 Pages 206
Published: 2005
Released on J-STAGE: July 25, 2005
JOURNAL FREE ACCESSDownload PDF (66K)
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