Sodium ions are the most popular ions in body fluids, and the sodium and water homeostasis is essential for animal life. Although the presence of sensing system for the Na
+ level in body fluids was postulated, its detail has long been an enigma. Recently we revealed that Na
x, a family member of voltage-gated sodium channels, is involved in the monitoring of the level of sodium ions in body fluids and sodium/water intake behavior. Here we introduce our studies about the sodium sensor in the brain.
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