Forty six healthy males were subjected to the inhalation of SO₂ gas of 1∼45 ppm for 10 min. through a mask from high efficiency gas chamber, and changes of clinical symptoms, respiration rate, pulse rate, vital capacity, 0.5 sec. expiratory capacity, Wright's expiratory peak flow rate were measured. The results obtained are summarized as follows: 1) The subjects did not complain any symptoms except few persons when they inhaled of 1∼5 ppm SO₂ gas. When exposed to 10∼30 ppm all subjects experienced a sense of burning of the upper respiratory tract, cough, chest-tightness, and in several persons moist rales in the chest were heard. 2) A slight increase of pulse and respiration rates was observed in about 10 percent of the subjects with no proportionate ralation to the concentration of SO₂. 3) The 0.5 sec. expiratory capacity and Wright's peak flow rate showed a liner decrease in proportion to the increase of SO₂ concentration, i.e. a decrease by 10 percent in 10 ppm and by 15 percent in 40 ppm. It was striking that vital capacity was observed to be constant. The lowest limit of SO₂ concentration which induced the bronch-consntriction was about 1.6 ppm. Within 10 min. after the inhalation the physiological changes returned to the preexperimental level. 4) When SO₂ of 15-41 ppm was inhaled several times for 10 minutes, the bronchial response tended to lessen in the grade and the subjects seemed to be accustomed to SO₂. 5) When the subjects inhaled broncho-dilator (Isoproterenol Hydrochloride) aerosols the constriction of brochus result from SO₂ was immediately released and no constriction by repeated SO₂ inhalation occured.

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With a view to profit to the prevention of driver's fatigue and traffic accidents, a study on man-machine system in buses and trucks-consisiting of drivers and driver's seats and controls-was made. Body dimensions of the driver's group, dimensions and locations of driver's seats and controls were measured, then adaptations between drivers and equipments were considered. On the other hand, maximum strength of extremities given to the controls-the steering wheel, levers and pedals-were measured, and then physiological standards about the dimension and the location of controls were considered. Results were as follows: 1) From the study of the dimentional adaptation between drivers and equipments, inadequate adaptation was found in several points-distance from the top of the foot pedal to the lower edge of the steering wheel, dimension of seats and range of seat adjustabilities etc. 2) As to the maximum strength given to the steering wheel, a) the nearer to 90 degrees stood the inclination of the wheel and the nearer to the body stood the wheel, the larger was the strength, b) the nearer to 0 degree stood the inclination of the wheel and the farther to the body stood the wheel, the larger was the strength: c) It seemed to be a good posture when the angle of elbow joint stood at 90∼100 degrees. 3) As to the maximum strength given to the lever, a) the larger the forward distance with which the lever stood, the lager was the strength, b) the larger the sideward distance, the smaller the strength; c) in the case of pulling backward, strength given in pronated position of the forearm was larger than that in a mid-position between the extremes of pronation and supination. 4) As to the maximum strength given to the pedal, a) the larger the forward distance with which the pedal stood, the larger was the strength, b) the larger the angle of the direction with which the pedal stood, the smaller the strength, c) it seemed to be a good posture when the angle of the knee joint maintained at 120∼130 degrees. 5) As to the ability to keep certain strength (5, 10, 15, and 20 kg.) against the pedal, the larger the strength, the lower the accuracy and the shorter the period during which that strength was sustained.

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The dose of X-rays from an electron microscope used at a steel works in Kobe city was measured. 225 mr/w, far over the permissible dose recommanded by I.C.R.P., was detected. The effect of protection of these X-rays by the use of 2mm lead protector around the electron gun was found satisfactory.

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A study was made of the effects of intravenously administered TEEP in rabbits on the surface and deep EEG patterns from uncleus caudatus, hippcampus, thalamus dorsomedialis and the reticular formation. Effects of PAM subsequently administered to the animals on EEG and ECG were also studied. 1 Following administration of TEPP the surface EEG patterns showed an initial increase of fast waves and an initial decrease of slow weves, followed by 34 c/s regular waves. 2 Following administration of TEPP slow weves with a large amplitude decreased and 34c/s waves with a small amplitude regularly developed in the deep EEG above mentioned. 3 ECG showed a marked bradycardia. EEG showed lower voltages as ECG showed bradycardic changes. 4 Immediately after the administration of PAM the bradycardia showed a dramatic improvement revealing a gradual recovery in EEG. 5 After the reapearance of each EEG by PAM, spike discharges were observed temporarily in the EEG's on nucleus caudatus, hippcampus and the frontal surface. 6 No changes were observed in the patterns of EEG and ECG following a sole administration of 60 mg/kg of PAM. 7 Antagonistic action of PAM against TEPP was observed in the central nerve system, though it was less marked than that in the heart.

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Lately we notice an increase of visitors at clinics in big cities, who come as out-patients with a good deal of complaints, esp. with a number of symptoms ascribable to circulatory and digestive disorders. Such cases are often found among night workers or those who are engaged in a busy, but monotonous, kind of work at offices, shops or factories in physiologically poor working environment, such as those deprived of the blessing of sunshine all day long, and may, therefore, be named "Night Worker's Disease" or "Building Worker's Disease (disease which affects a person who either works or lives in a concrete building)". The author attempted to analyze such disease conditions from clinical point of view. Subjects of study were females in the 18-31 age bracket, without fever, leucocytosis and abnormal roentgenological findings of the chest-so that organic and infectious diseases might be excluded-and also free from parasitic diseases as ascertained by fecal examination, and with no serious menstrual disorders. Group I consisted of 9 shop-girls with heavy complaints who were working on the basement floors of department-stores, Group 11 12 clerks also with heavy complaints, Group III 14 girls who were working in bars or cabarets, and the control group 14 healthy girls. As a result of the comparative study of 47 such cases, the following findings were obtained: (1) Re. symptoms, cold limbs, palpitation and other symptoms of circulatory system, pyrosis nausea, epigastric distress, constipation and other symptoms of digestive system, as well as vartigo and stiffness of shoulders were seen in high frequencies in all of the three subject groups. Furthermore, night worker's group was seen to develop additional symptoms which might be ascribed to nervous system, such as headache and insomnia. (2) Weight/height ratio was markedly lower in Groups I and III than in the control group; and the mean (average) arterial blood pressure was significantly lower in Group III. 3) Re. blood picture, both hemoglobin values and red-cell counts decreased in the three groups as compared with the control group; M.C.V. more or less increased in all the three groups, most conspicuously in Group III. (4) Decrease of serum-albumin values, Gros Volues (SHIBATA's method), serum-cholesterol values and serum K/Na was detected in all of the three groups-esp. in Groups II and III to a high degree. (5) By electroca diographical study, increase of QT ratio and decrease of ventricular gradient were observed in all of the three subject groups. (6) By experiment on rabbits in starvation, the above-mentioned results were successfully reproduced as regards body weigth, hemoglobin values, serum-albumin values, K/Na and electrocardiographical findings i.e. QT ratio and ventricular gradient. On the ground of such findings, it was observed that those in physiologically poor conditions developed more or less distinct clinical signs and symptoms similar to those seen in the state of undernutrition, esp. hypoalbuminemie, and that, in view of the developmental stage of the disease condition, the status of "Building worker's Disease" among daytime workers might be safety classified as the transitive atate from good health to "Night Worker's Disease"

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