巻号一覧
16 巻, 9 号
選択された号の論文の4件中1～4を表示しています
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角原 孝1974 年 16 巻 9 号 p. 839-852
発行日: 1974/09/30
公開日: 2011/07/04
ジャーナル フリー1971年来われわれは免疫グロブリンおよび補体成分C'/3レベルの面より腎炎病態のアプローチを行なつている。今回IgEを中心として,従来よりselectivity indexとして使用して来たIgGとの相対的動態を通して腎炎またはネフローゼ症候群の病態研究を行ない,以下の結論を得た。(1)血中IgGとIgEとは異つた動態を示す。(2)血中IgEレベルはindeterminate group neph-rosisで有意の高値を示す。(3)IgG,IgEの補体結合性差異を示唆する相関性が得られた。(4)腎炎またはネフローゼ症候群の免疫機序には,少くとも4つのpatternが推定される。iネフローゼ症候群indeterminate groupに見られる高IgE・高補体価性pattern ii慢性膜性増殖性腎炎にみられる低補体価性pat-tern iiiネフローゼ症候群mernbranous typeにみられる相対的高IgG・高補体価性pattern ivその他一般的non-specific pattern(5)従来のselectivity index評価には,小分子化蛋白の関与も考慮する必要がある。(6)IgE分子もIgG分子同様,GBM通過をなすと推論される。抄録全体を表示PDF形式でダウンロード (1358K) -
追手 巍1974 年 16 巻 9 号 p. 853-861
発行日: 1974/09/30
公開日: 2010/07/05
ジャーナル フリーImmunological deficient state in chronic renal failure was studied by evaluating the subpopulation of peripheral lymphocytes, quantitatively and qualitatively in 54 patients treated with long-term hemodialysis. In addition, PPD skin reaction, hepatitis-B antigen and antibody, and immunoglobulins and beta 1 C/A globulin in sera were determined. By comparing these immunological parameters with the lymphocyte subpopulation, the following results were observed in the hemodialysis patients. 1) The percentages and counts of T-cells were significantly lower than in the healthy subjects (per 0.001).2) The PHA-induced lymphocyte transformation was significantly impaired (p<0.05). 3) There was, however, no demonstrable differences in percentages and counts of B-cells in contrast to the healthy group. 4) The immunoglobulins (IgG, IgA and IgM) and beta 1 C/A globulin were almost within normal ranges. These observations suggest that the cell-mediated immunity is particularly impaired in chronic renal failure while the production of circulating antibodies is essentially unaffected on the whole.抄録全体を表示PDF形式でダウンロード (1023K) -
Takao Nagai1974 年 16 巻 9 号 p. 863-876
発行日: 1974/09/30
公開日: 2011/03/01
ジャーナル フリーPDF形式でダウンロード (19118K) -
東福 要平, 上野 敏夫, 木藤 知佳志, 黒田 満彦1974 年 16 巻 9 号 p. 877-886
発行日: 1974/09/30
公開日: 2011/07/04
ジャーナル フリーA 24 year-old female patient with renal failure associated with sarcoidosis was reported. Diagnosis for sarcoidosis was based on the findings such as BHL on chest roentgenogram, turbidity of the retina, positive for Kveim test, epithelioid granuloma in the biopsy specimen from her leg nodule, high ESR, hypergamm-aglobulinemia and hypercalcemia. Other laboratory data disclosed mild renal insufficiency ; mild proteinuria, elevation of BUN and serum creatinine, and decreased GFR and RPF. X-ray examination of the kidney showed large kidneys with irregular contour, but without nephrocalcinosis. Renal scintigram showed many coin-like lesions bilaterally. Histologic examination of renal biopsy specimen revealed severe interstitial nephritis with hyaline necrosis, but without calcium deposition. It is reasonable to pressume that renal failure was due to the involvement of sarcoid granulomata to the kidney, although neither epithelioid nor giant cells could be found out in the renal biopsy specimen. Porcine calcitonin was administered prior to corticoid therapy which improved her general conditions. Calcitonin was effective to lower serum calcium and inorganic phosphate levels. Of particular interest was the decrease of urinary phosphate excretion as well as calcium excretion, despite of constant urine volume and creatinine clearance during calcitonin administration. Hypercalcemia in this case was assumed to be due to the increased state of bone resorption.抄録全体を表示PDF形式でダウンロード (5384K)
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