Periodic changes in liver volume caused by the intravenous injection of Ringer' solution, sodium citrate solution, into urethane-anaesthetized dogs, were observed. The periods were from 15 to 38 seconds and the most frequent was about 25 seconds. This change can be divided into that caused by active contractions of the liver (Fig. 1, 2) and that caused by a passive change (Fig. 3). The fact that the active contractions of the liver caused about 10% change in portal venous pressure was also demonstrated.

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This report is based upon the E. C. G. studies on 60 murine typhus patients, who entered in this hospital since the end of 1947. Of these, tracings were taken frequently to record successive changes, especially in 43 patients. According to my observation, low amplitude of T waves (less than 0.2mV) 37 percent, low voltage 10 percent, were the most conspicuous findings which may well indicate the presence of myocardial damage. These alterations were usually more striking in fever period. PQ interval showed no significant deviation, but QT time, when caluculated by Hegglin & Holzmann's formula, showed the tendency of prolongation even in the begining of defervescence period, and this prolongation lasted usually for sometime after the recovery. The recovery of E. C. G. changes of the patients who administered PABA. Aureomycin, chloromycetin and terramycin were fairly conspicuous, but less dramatic when compaired with the recovery of other clinical symptoms.

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Maekawa's Standardized Local Leads are relative unipolar (chest and esophageal) leads, and are characterized by examining the relation of position between the heart and the exploring electrode. By this method the ventricular curves in the esophageal leads have been investigated theoretically. On any point on the left auricle the ventricular vector is observed from the electronegative side, also als the electronegative potential. Near the lower pole of the left auricle (ca. 38cm from insicur-tooth) the ventricular initial deflection is of the maximum amplitude, and that electronegative deflection represents the potentialvariations in the apex and the right ventricle, and that electropositive deflection represents the potentialvariations in the posterior wall of the left ventricle. The local potentialvariations on the posterior wall of the left ventricle can be led unipolarly not only on the basal portion (ca. 40cm) but on the diaphragmatical surface(ca. 46cm), especially in the case of the left ventricular hypertrophy.

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Myocardial infarction was caused in the rabbitts and guinea pigs by injection of 1% trichlor acetic acid or ligation of a branch of coronary artery. Relationship between the change of the initial deflection of ecg and histologic findings were observed. And for purpose of detailed analysis, Φ_A (the largest vector) and θ_R (its direction) were calculated by means of the orthogonal isoscale triangle coordinate (Maekawa). This paper described about 5 cases, which Φ_A increased when animals were killed. Results were as following. 1. S-T interval deviated upwards and ecg was monophasic after the operation, in progress of the time became the S-T deviation lesser, T wave neared to the base line and then became negative. 2. Φ_A in these cases was 110-196% of its account before theoperation. Φ_A in 4 cases increased immediately after operation. 3. θ_R in 2 cases deviated to the left, in 2 cases to the right, in 1 case became in the opposite direction. 4. The apperant width of infarction was 5×5-15×20 mm and also the extension of damage was localized superficially and corresponded to the appearant extension. The compensative hypertrophy of muscles was found.

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