A 31-year-old man complaining of syncopal seizure, chilly sensation of the lower extremities, stiffshoulder, tinnitus, headache and palpitation was admitted in August 30, 1955 with a diagnosis of malignant hypertension. On his death, November 29, 1955, autopsy found cerebral hemorrhage, cardiac hypertrophy, congested kidneys and intensive stenosis of the abdominal aorta.

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In Masugi-nephritis, mild Masugi-nephritis and anaphylaxis of Masugi-nephritis, a study was made of urinary protein and serum protein on electrophoresis as well as on histological aspect.In serum protein of Masugi-nephritis, the following phenomena were observed : total protein showed an increase at the early stage and a remarkable decrease after the appearance of proteinuria ; albumin fraction showed a decrease after sensitization and a more remarkable decrease after the appearance of proteinuria ; globulin fraction showed an increase after sensitization and a more increase after the appearance of proteinuria ;α-globulin fraction showed the maximum before the appearance of proteinuria ;β-globulin showed the maximum after the appearance of proteinuria ;γ-globulin showed an increase after sensitization and a slight increase after the appearance of proteinuria.In mild Masugi-nephritis, each fraction showed slight changes with the same tendency as in Masugi-nephritis.In the control case of normal-duck-serum, there were observed a decrease in total protein and a decline of A/G, the latter being less in degree than that of Masugi-nephritis.An increase of globulin fraction chiefly depended upon that of γ-globulin fraction but not upon a slight increase of both α-globulin fraction and β-globulin fractions.In anaphylaxis of Masugi-nephritis, a decrease of γ-globulin fraction was found after an hour. The result after 84 hours revealed that total protein and albumin fraction had decreased but α-globulin and β-globulin fraction had increased.The above mentioned result showed some resemblance to the result obtained after the appearance of proteinuria in the case of Masugi-nephritis.In Masugi-nephritis, the urinary protein is consisted of fractions excluding fibringen in plasma protein, that is, albumin fraction, α-globulin fraction, β-globulin fraction and γ-globulin fraction. Albumin fraction, however, occupies the majority of the components.Proteinuria on the 9th day after sensitization, compared with that of the 14th day was generally low in albumin fraction and high in γ-globulin fraction.Histologically, pathological changes of typical glomerulitis were found in Masugi-nephritis, while in slight Masugi-nephritis they were milder than in the common cases. In anaphylaxis of Masugi-nephritis there was also found a similar glomerulitis.

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With pituitary-adrenocortical hormon (DOCA, Cortisone and ACTH) administed to rabbits with Masugi-nephritis, a study was made of the influence of these hormones on the appearance of nephritis from the view points of variation of blood pressure, albuminuria, a decrease of the complement and the variation of serum protein accompanied by a histological survey.(1) When DOCA was given, variation of blood pressure, the appearance of albuminuria and a decrease of the complement were found at the earlier stage than a control case.It was also considered that the appearance of nephritis and severity of the disease were accelerated, on the basis of serum protein and from a histological view point.(2) In case of Cortisone and ACTH, as to variation of blood presure, the apperance of albuminuria and a decrease of the complement, changes were not so remarkable as in a control case. In that respect Cortisone and ACTH did not seem to check the appearance of nephritis.Although it was interesting that some qualitative variation had developed in Masugi-nephritis, pathological changes in the glomerulus had been mitigated especially following the administration of Cortisone. Still, a nephrotic pattern was indicated in serum protein of each case as mentioned above.

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Prof. MAEKAWA proposed Rectangular Isosceles Triangle Coordinate, which is considered more true to nature than Einthoven's Triangle Scheme. According to this coordinate, the right arm and left leg lead points constitute the both apexes of the hypotenuse of this triangle. When the magnitude of the potential of each limb lead point is designated ΦR, ΦF and ΦL, respectively, ΦR=-(II)/2, ΦF=(II)/2, ΦL=(I-III)/2.We have studied merits and demerits between the both coordinates, theoretically and practically. The results are as follows.(1) Mathematical relationship is found between the results analyzed by Einthoven's Triangle and those by Maekawa's Rectangular Isosceles Triangle Coordinate. (i) The vector rotation in a cardiac cycle is in the same direction, whether analyzed by the former or by the latter. (ii) The magnitude of the vector potential on the frontal plane analyzed by Einthoven's Triangle is 1.15-0.67 times greater than that by Maekawa's Coordinate.(2) When the magnitude of the potential of the central terminal is designated V₀ in Eithoven's Triangle and Φ₀ in Maekawa's Coordinate, respectively, V₀-Φ₀=VL/2=ΦL/3 Consequently, when VL≒0 or ΦL≒0, V₀≒Φ₀ (3) In clinical practice, Rectangular Isosceles Triangle Coordinate is more convenient and of more value in comparison with Einthoven's Triangle Scheme, mostly because the former is a rectangular coordinate.

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The author have studied the significance of the "wedge pressure" in the cardiac catheterization of dogs.1) The experimental pulmonary arterial hypertension induced by pulmonary embolism does not accompany pulmonary arterial wedge pressure elevation.2) At the normal lung, contour of pulmonary venous wedge pressure showes typical arterial pressure contour, in contradiction to this, pulmonary arterial wedge pressure contour showes venous pressure contour. The pressure difference between them are averaging at 4.8 mHg.3) In the ventricular premature beats, which fails atrial contraction, pulmonary arterial wedge pressure contour showes n oa-wave and chiefly composed by v-wave.4) According to these datas, the author have set a shema, which explaines that the pulmonary arterial wedge pressure is idential with pulmonary venular pressure and the pulmonary venous wedge pressure with pulmonary arterial pressure. According to the former concept of "velocity factor" the author have calculated the pressure difference between the pulmonary arterial wedge pressure and the pulmonary venous wedge pressure as less than 0.58 mHg, which is far small as to explain practical difference of 4.8 mHg.

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