Introduction Numerous reports about bacillemia of rheumatism and tuberculosis have been published. Especially, GUTZEIT & PARADE explained clearly dependent upon the allergic theory the difference between focal infection and septicemia (sepsis). Therefore I thought I had to confirm that there was no bacillemia during sensitization in my own first experiment, to certify that the previous histological changes in myocardium would be truely allergic or not. In this report I tried to cultivate tubercle bacilli from each blood of the all animals first experimented during the latter sensitizations and before and after the reinjection and further to inoculate each blood of them on guinea pigs after the last sensitization. Result These results have clarified that there was no bacillemia during and after sensitization. The degree of bacillemia after the intravenous reinjection was not parallel to each milligram of the reinjected tubercle bacilli.

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Discussion and Conclusion I sensitized frequently the rabbits intratesticularly by tubercle bacilli with rabbit-myocardium-phosphatide and further reinjected them intravenously. On the one hand I examined clinically, serologically and histologically and on the other hand bacteriologically for tuberculous bacillemia. The observations are as follows: 1) In these experiments, body weight, temperature, blood pressure, blood picture, roentgenogram and etc. showed clinically no remarkable changes, but ecg.lly and serologically the existence of myocardial damage was recognized. Urobilinogen and urobilin reactions in urine were temporarily positive after frequent sensitizations. Tuberculin test indicated a pretty hight tuberculin-allergy. 2) Histologically, the diffus interstitial myocarditis and cardiac muscle fiber degeneration were observed more intensely compared with the control and especially perivascular granuloma (so-called rheumatoid or tuberculoid) in myocardium in one of the cases. 3) Bacteriologically, there was no bacillemia during and after frequent intratesticular sensitizations. The conclusions are as follows: 1) These histological changes in myocardium are of allergic nature. 2) This rabbit-myocardium-phosphatide makes tubercle brcilli even by intratesticular sensitization well adhere to its myocardium.

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The conclusions are as follows: 1) Clinically; body weight, temperature, blood pressure, blood picture, roentgenogram and etc. showed no remarkable changes. Protein, urobilinogen and urobilin reactions in urine were temporarily or continuously positive after the reinjection. Ecg. indicated myocardial damage. Serologically; PPR. before and after the reinjection were positive. 2) Histologically; on the one hand in the heart the diffus interstitial myocarditis and KLINGE's perivascular granuloma were seen, on the ohter hand in the lung slight changes. 3) In this experiment I could not produce the soecific allergic changes in the lung tissue successfully. The fact that I found more intense allergic changes in the heart than in the lung will suggest that the rabbit-lung-phosphatide consists of a component which has an intense affinity to the heart. Therefore I think that I must try to remove this component from the rabbit-lung-phosphatide in the future.

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In this paper, I applied the results of potential measurements in previous report to the discussion of various problems in the clinical electrocardiogram and the vectorcardiogram. 1) From the potential value due to the activation of each unit muscle region of ventricle, I could determine the most effective ventricular region to each point of unipolar chest lead and found these results coincided well with those of Wilson and of Rosenburg. 2) I knew that the Vectorpolyography of Toyoshima was the moset excellent method to represent the electrical heart axis as the vector when we compared the manifest resultant vectors by various ground to select the leading points of Vectorpolyography in each plane as follows. a) Frontal plane. The eight points having same distance each other on the circle drawn on the back surrounding D_9 with radius 10 cm. b) Horizontal plane. The eight points surrounding the trunk in same distance at the navel level. c) Sagittal plane. Four opposite points on the preaxillar and postaxillar line at the 2-nd and 8-th intercostal levels. 3) I supposed two processes of ventricular activation modifieing the assumptions of Lewis and of Barker and traced Vectorpolyogram, unipolar chest lead and standard limb lead electrocardiogram by calculation following to these processes. The results of these calculation were resembled closely with those of vectorcardiogram and electrocardiograms of normal adult. 4) In the Vectorpolyograms obtained by calculation, the initial direction of QRS loops of ventricular premature beat were coincident well with direction of inward normal at the stimulated point like as the experimental results of Toyoshima and Yamada on toad heart. 5) The unipolar chest lead tracings, derived as a scaler projection of horizontal vectorcardiogram, did not correlate so close with actual unipolar chest lead tracings as Lasser and his coworkers noted.

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Using rabbits, the author succeded in getting congestive heart failure by giving large quantity of salt in addition to experimental aortic or pulmonary stenosis and investigated by using dye T-1824 the changes which lead to congestive heart failure. Influence of salt on such rabbits as in experimental aortic or pulmonary stenosis does not qualitatively differ, but differs only in degree from it on normal ones. Changes stated in part IV are only magnified in such conditions.

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