Intending to make a research on the motion of the heart at quiet standing position of 8 patients who have no cardiac disease, and the following resalts were discovered. 1. Each diameter, area and capacity can be represented in a regular curve which coincide with pulsation of the heart and they were influenced by motion of respiration and have a contact relation to the diaphragm motion curve. 2. Area of diastole and systole of the heart and difference between these two were influenced a little by respiration and have approximately constant numerical number. Diastolic and systolic capacity and output of the heart are constant and will not be influenced by respiration. 3. Greatest distance of the left border of the heart shadow from the medianline is almost twice as wide as that of the right and the former is obviously influenced by respiration. Phase of the curves of the greatest distance of the right border of the heartshadow from the medianline and upper transverse distance proceeds somewhat earlier than the phase of the greatest distance of the left border of the heart shadow from the median line and lower transverse distance. 4. All diameters, areas, capacities and output of the heart increase together with age and reach in adult at maximum. Proportion of disparity to each area of pulsation and proportion of output of the heart to each capacity is the younger the larger, i. e., the younger the age, the more vigorous is activity of the heart.

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1. The parts where vitamin D-arteriosclerosis were caused and progressed on the rabbit's pulmonary arteries, were established as following: a. On the convex surface of the blood vessel's curuing, b. On bifurcating parts of the blood vessels. On these parts, sclerotic changes were beginning to occur before bifurcating, progressing powerfully on the inside thigh of bifurcating point, and decreased or disappeared soon after the completion of bifurcation. On the branches, these changes were occurred more powerfully on the bigger one. 2. Owing to the ovoral-giving, there were formed sometimes aneurysms on the pulmonary arteries of the rabbit.

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About this inyocardial phosphatide reaction (CPR) the following examinations were performed. 1) Relation to serological reaction in syphilis: If the inyocardial phosphatide was purifid, both reactions had not intimate relations. 2) Relation to proteids quantity in blood-plasma : Both had not intimate relations. 3) Relation to red cell sedimentation rate: Many persons, who had quick sedimentation, had tendency to produce the positive reaction in CPR. 4) Relation to Takada's reaction: This reaction coincided with CPR(43%). 5) Component of the myocardial phosphatide: It had not cholesterol, proteids and aminoacids. If this material was hydrolysed, the Molisch's reaction was positive. 6) Euglobulin concentration : Three times dilution of euglobulin was properest. 7) Question of racespeciality : It was not recognised.

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The author calculated the vector (θR & φA) of the electric charge of the hearts of the P-puhnonale by the standard EKG by means of Maekavxt's orthogonal isosceles triangle coordinates. As a whole these are inclined to right, and their rotations are less than the healthy men: and φA are remarkably long, but their continuous times are not so different with healthy men. These are seemed to be caused as follows: to consider the P-wave as previous two report, the times of the stimulous conduction in pathologic right auricles are prolonged, therefore the double times of stinmlous conduction of both auricles are prolonged. Then the author agrees with Takayasu's proposal that such P-wave should be called as "Eight Auricular Predominance".

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(V) The patho-histological Observation of the second Experiment I examined all organs of the second experiment rabbits patho-histologically and found the weaker and smaller number of tubercle than in those of the Control animals. What we should pay attention particularly in myocardium were these following results, 1) the figure of the remarkable'mesoarteritis was recognized, 2) the intense basophilic cell infiltration was recognized. 3) the rheumatoides were not recognized.

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(VI) Conclusion I sensitized the experiment rabbits by tuberclebacillus with the rabbit-heart-muscle-phosphatide and after 3 to 9 weeks injected the same. The observations of there are: 1. The clinical observations : No noticeable change in body-weight was recognized, slight change in blood pressure, body temperature and bloopicture were seen. In electrocardiogram, particularly after reinjection, a remarkable decline of ST_2, ST_3 and a Conspicious elevation of T_2 were recognized. 2. The patho-histological observations; At the first experiment, the heart of the experiment rabbits showed a great many rheumatoids. At the second experiment, the experiment rabbits showed the noticeable mesoarteritis and the severe basophilic cell infiltration. 3. These results proved the fact that when intensely sensitized and reinjected by tubercle bacillus with heart-nmscle-phosphatide : a) The interstital myocarditis with the Aschoffnodule-like granuloma can be occurred. b) The heart-muscle-phosphatide makes tubercle bacilli adhere to the myocardium. c) The mesoarteritis and intense basophilic Cell infiltration Can be occurred.

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The author devised and made a certain suction apparatus which is able to observe the Capillaries during the whole time of the application of negative pressure. Applicaling-200mmHg with this apparatus. he investigated the changes of capillaries on 50 normal adults, and obtained the following results. Whole the capillaries were expanded, blood filling was increased, base colour Avas strengthened, blood flow was delayed or stopped, and the edema appeared on all Cases. Also observed the capillary bleedings and the increase of number of visible capillaries on some cases.

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The study was made on the change of capillaries with respect to body temperature and blood pressure, before and after schwefelin or gonococcen-vaccine injection by which meant to cause therapeutic fever, on 7 patients. The following results were obtained: At the stage of raising of temperature, the blood pressure increased with raising of temperature and the capillaries contracted or showed a tendency to contract. The blood pressure decreased at the hot stage, especially markedly at the lowering stage of temperature with sweating. The capillaries dilated and elongated. The blood circulation in the capilla-, ries became more rapid. The number of visible capillaries increased. Strengthening in the base color tone was noted, especially remarkedly at the sweating stage. With removal of fever, the blood pressure and the build of capillaries almost returnedto thepre-injection state. From the above results, it seems possible to consider that there is close connection between the changes of capillaries, blood pressure and temperature, in therapeutic fever.

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