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Volume 9 (1962)
- Issue 4 Pages 247-
- Issue 3 Pages 161-
- Issue 2 Pages 81-
- Issue 1 Pages 1-
Volume 9, Issue 1
Displaying 1-7 of 7 articles from this issue
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KYOKO HIGASHI1962 Volume 9 Issue 1 Pages 1-11
Published: 1962
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSFurther fractionation of the active substances extracted from the human placenta at the later stage of pregnancy was carried out by urtracentrifugation and two fractions, Fractions UA and UB, were obtained.
These substances are glycoproteins, namely Fraction UA contains fructose and glucose, whereas Fraction UB contains mannose and galactose.
Fraction UA contains mainly a component with sedimentation coefficient of 2.4 (2.4 S-component) and Fraction UB contains mainly that of 4.3 (4.3 Scomponent). The 4.3 S-component possesses the activity of increase of the size and number of fatty granules in the crop milk of pigeons. The 2.4 S-component possesses the activity on the proliferation of mucous membrane of crop-gland.
The 2.4 S-and 4 3 S-components have the molecular weights of 45, 000 and 80, 000, respectively. These components, therefore, seem to be different from the pituitary lactogenic hormone.View full abstractDownload PDF (2665K) -
MICHIO UI1962 Volume 9 Issue 1 Pages 12-21
Published: 1962
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSIn vitro effect of serotonin on glycogen level of rat diaphragm was investigated. Serotonin stimulated glycogen formation in phosphate-buffered saline, but not in Krebs-Ringer bicarbonate medium.The effect of serotonin disappeared under glycogenolytic condition.Glucose uptake was never augmented by serotonin even in the tissue in which glycogenetic action of serotonin was exhibited.Suppressive action of serotonin on glucose uptake manifested itself in diabetic as well as in glucose-fed non-diabetic rat tissue.The negative interaction was noted between glycogenetic activity of insulin and serotonin.The mechanism involved in in vitro effect of serotonin with respect to stimulation of glycogenesis and inhibition of glucose utilization is discussed along with the comparison to insulin.View full abstractDownload PDF (1017K) -
MICHIO UI1962 Volume 9 Issue 1 Pages 22-32
Published: 1962
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSWhen rat diaphragm was incubated in serum, the glycogen level of diaphragm incubated in serum of the serotonin-treated rat was higher than that in control serum. Either cysteine-treatment of the serum or induction of alloxandiabetes in serum donor rats completely abolished this effect. Thus it was concluded that subcutaneous administration of serotonin resulted in an enhanced secretion of endogenous insulin. With the diaphragm obtained from serotonintreated rat, in vitro effect of insulin or epinephrine disappeared in phosphatebuffered saline but not in Krebs-Ringer bicarbonate solution. Diaphragms excised from alloxan-diabetic rats treated with serotonin was found to exhibit the ordinary response to insulin and epinephrine in either incubation medium. Since preincubation of diaphragm with insulin abolished the effect of added insulin in further incubation in phophate-buffered saline, but not in Krebs-Ringer bicarbonate solution, serotonin-treated tissue was assumed to be bound with endogenous insulin as a result of accelerated pancreatic secretion. A possibility was suggested that serotonin is a physiological accelerator of insulin secretion in organism.View full abstractDownload PDF (1041K) -
MICHIO UI, BONRO KOBAYASHI1962 Volume 9 Issue 1 Pages 33-40
Published: 1962
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSStimulatory effect of serotonin on lactate production of rat diaphragm was examined in Krebs-Ringer bicarbonate solution. At a dose of 50μg per flask, clear-cut effect obtained when incubated with diaphragm from glucose-fed rat, but inconsistent result was noted in diaphragm from fasted rats. When dose of serotonin was raised to 200-250μg, lactate production was stimulated by serotonin without fail even in fasted rat diaphragm. Simultaneous occurrence of enhanced glucose uptake and glycogenolysis was observed when serotonin of high dose (200-250mu;g) was employed, whereas increase in lactate production elicited with 50μg serotonin was never accompanied by augment of either glucose uptake or glycogenolysis. When the amount of lactate produced due to neither enhanced glucose uptake nor glycogenolysis was calculated, effect of serotonin of 50μg was evident in this term in fasted or fed rat diaphragm, suggesting that serotonin, incontrast to insulin or epinephrine, more or less directly increase lactate output from endogenous intermediaries.View full abstractDownload PDF (705K) -
HAROLD S. FLEMING1962 Volume 9 Issue 1 Pages 41-56
Published: 1962
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESS(A) 1. Parotin administration affected both the exocrine and endocrine pancreases of mice.
2.β cells seemed increased and islets were larger and more numerous in the treated mice.
3. Serum glucose was depressed after parotin was given.
4. Ductal epithelium showed proliferation and increased cellularity in the experimental animals.
5. Vascularity was increased in both the exocrine and endocrine pancreases where parotin was given.
6. Adrenals showed increased vascularity and Zone X near the medulla had more cells and was wider in treated animals.
(B) 1. There was better survival of anterior chamber guinea pig homotransplants of fetal pancreatic tissue when parotin was given.
2. Vascular increases to the transplants was observed soon after each parotin injection.
3. Pancreatic islet tissue was more definitive histologically in parotin injected hosts.
4. Cystic formations were more pronounced in the non-treat control host.
5. Ducts appeared to be more functional in the treated hosts.
6. The exocrine in situ pancreatic tissue of treated hosts showed a difference in gross appearance and histologically there were unusually high areas of fat cells.View full abstractDownload PDF (24041K) -
YOSHIKO MORITA, TERUKO KAMEI1962 Volume 9 Issue 1 Pages 57-65
Published: 1962
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSAfter hydrocortisone administration the activity of hepatic glutamic pyruvic transaminase (GPT) and the activity of hepatic arginase were followed with time and at the same time the weight of some organs and the content of liver protein were also measured in female rats.
GPT and arginase activities reached maximum levels at the 6th hr. after single subcutaneous injection of 2mg/100g body weight of hydrocortisone. Daily injection of the same dose for 7 days caused 2 times the increase of GPT activity and 1.5 times the increase of arginase activity as compared with controls. There was a striking parallel between these enzyme activities increased by hydrocortisone.
While the weights of the adrenal gland, thymus and spleen remarkably decreased, those of the liver, kidney and heart increased, and the weight of the thyroid did not change after daily administration of hydrocortisone. A sharp increase of liver weight was noticed at the 16th hr. after single injection.
The influence of hydrocortisone on the liver protein content was not significant.View full abstractDownload PDF (666K) -
TOMOKO FUJII, RYOSHU KOYAMA1962 Volume 9 Issue 1 Pages 66-73
Published: 1962
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSThe contents of DNA and RNA were determined in various organs in intact rats, male or female, during the postnatal growth.
There was no sex difference in normal value of both nucleic acids, but an evident correlation between the content and age; the most organs showed higher concentration of nucleic acids in very early period of the postnatal growth.
In general, the DNA level showed a decrease during earlier periods of growth, maintaining a lower value after about 4 weeks of age. The RNA amount varied depending upon organs but not so marked as DNA level.
These changes are correlated with the sexual maturation, and especially conspicuous relationships were observed in reproductive and accessory reproductive organs, i. e., in these organs, the level of DNA was higher than that of RNA in earlier stages, and this relation was reversed in later stages.
There was no change in amount of both nucleic acids in such organs as the thymus and ovary.View full abstractDownload PDF (554K)
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