After the intramuscular injection of testosterone cyclopentyl propionate (TCP), the followings were observed.
In the injected part, only TCP was chromatographically detected within the6 days at leat, but not later after the injection, suggesting that the injected TCPremained in the injected part without serious decomposition and almost all wasabsorbed more slowly than testosterone or its propionate in the same solvent.
In the blood of portal vein, TCP and possibly testosterone were measurable, but never in the peripheral blood.In the urine and bile, TCP and the two othersteroids which were chromatographically identical with testosterone and dehydroepiandrosteronerespectively were detected.
From the quantitative observation of the above mentioned results, it wasdeduced that thus absorbed TCP were deposited in the entero-hepatic circulationand gradually converted to free testosterone.

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1) Eighteen male and 18 female rabbits were intravenously injected with glucose and curves representing change in blood sugar level were classified into 4 types-exponential, humped curve, sigmoid and straight line-the frequency of each type being investigated.It was found out that the humped curve type had the highest frequecy for the rabbit occurring in half of all the examined cases, and the exponential type only in 1/4.There was no difference by sex in the frequency.
2) Animals of the humped curve, the sigmoid and the straight line types tended to have lower insulin sensitivity.
3) The administration of insulin tended to transform all types other than the exponential one into this.This effect was more evidently demonstrated when zinc-protamin-insulin was subcutaneously injected 20hours before the glucose administration than when the regular insulin was given together with glucose.

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1) The fitness of the intravenous glucose tolerance curve to an equation in consecutive monomolecular reaction_??_was investigated with 22 cases of rabbits, and it was found out that the curve which appears 23-103 minutes after the injection of glucose is expressed by the above mentioned equation.
2) When the interval between the bleeding times was 20 mins., the values of e^-k1 and e^-k2 calculated from the results from 22 normal rabbits were 0.628 ±0.186 and 0.462 ±0.325, respectively, and e^-k1 seems to express relatively well the glucose tolerance of the living body.

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Histological study of the eminentia mediana was carried out on the brainsof 16 horses with the following results.In 10 specimens examined, significantaccumulation of neurosecretory material was observed in the perivascular spacearound the primary capillaries of the hypophysial portal system and also overwide area of the outer surface of the eminentia.Such a picture was closely relatedto pronounced corrugation and complicated texture of the outer surface of theeminentia, and the site in question serves as a significant contact surface betweenthe hypothalamic neurosecretory system and the hypophysial portal vessels as wellas the tissue of the pars tuberalis.A view that the proximal part of the dorsalwall of the eminentia bears the primary significance as the site of neurosecretorysupply to the adenohypophysis was introduced.

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Present study was carried out to obtain simple and considerably accuratemethod for measuring mammary duct areas in mice treated with estrogen.
Normal and gonadectomized Kasukabe mice in both sexes were injected onfive occasions subcutaneously with total dose of 12.5 I.U.of synthetic estrogenfrom 20 days old.On the 35th day mice were killed and the third thoracicmammary glands were prepared by whole mount method.Preparations wereenlarged on section paper and such four methods as A) Index of mammaryduct area method, B) Planimeter method, C) Calipers method-1, and D) Calipersmethod-2 were used to compare the properties of four measuring methods.Results obtained are as follows.
1.Planimeter method is comparatively reliable among B), C) and D) method.
2.There are close associations between mammary duct areas measured byA) and B) method.Correlation coefficients are 0.85 in female, 0.95 in castratedfemale, 0.94 in male and 0.77 in castrated male.
3.The differences of mammary duct areas between normal and gonadectomizedgroup are not significant in each sex but the difference between sexes issignificant statistically.When normal and gonadectomized group's data in eachsex are combined, means with fiducial limits by B) method are 175.3±4.6 infemale and 179.8±8.2 in male when the mammary duct areas measured by A) method in each sex are placed as standards respectively.

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1.No remarkable difference between the contents of oxytocic principle in posterior pituitary of male bovine and female was found.
2. Oxytocic substance was extracted from human and rabbit urine.This substance was contained more in rabbit urine than in human urine.
3.This oxytocic substance extracted from male urine had higher potency rather than that of female urine.
4. Urinary oxytocic substance gave same properties as posterior pituitary extract in counter-current distribution, paper chromatography, electrophoresis and amino acid composition.

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1.Histamine was not detected in urinary oxytocic substance.This substance contracted rat uterus, so it is considered that oxytocic activity of urinary extract is not due to hitamine-like substances.
2. Oxytocic activity of urinary extract was decreased by the treatment with sodium thioglycollate, and it did not lose its potency by dialysis of 30 min.but the potency decreased by dialysis of more than I hour.
3.This substance had not only oxytocic effect (4 I.U./g), but antidiuretic effect (3.9 I.U./g) also.

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The growth-promoting effects of STH and parotin were studied under feedingwith fluid diet.STH stimulated effectively the body growth in hypophysectomizedand sialoadenectomized immature rats.Smaller and larger doses of parotin couldnot promote the body growth in hypophysectomized and/or sialoadenectomizedanimals.Moreover, as the extirpation of salivary glands did not arrest the normalgrowth in growing rats, it would be said that the salivary glands do not participatein the body growth, directly.

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Hypophysectomized and/or sialoadenectomized immature female rats were administered with STH or parotin in order to detect histologically the skeletalgrowth promoting effect of parotin compared with that of STH.
The results obtained are as follows:
1) Endochondral ossification in the proximal tibial epiphysis was reactivated by the administration of STH in either hypophysectomized or hypophysectomized and sialoadenectomized rats.
2) Under the conditions employed in this experiment, neither administration of parotin nor the removal of the salivary glands caused any pronounced histological changes in the proximal epiphysis of the tibia.

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