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Volume 10 (1963)
- Issue 4 Pages 215-
- Issue 3 Pages 159-
- Issue 2 Pages 93-
- Issue 1 Pages 1-
Volume 10, Issue 4
Displaying 1-6 of 6 articles from this issue
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NOBUAKI SASANO, MICHIKO FURUYAMA, MASAYOSHI YAMAZAKI1963 Volume 10 Issue 4 Pages 215-220
Published: 1963
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSA rare autopsy case of congenital adrenal hyperplasia combined with agenesis of the gonad and adnexa was reported. The patient was a newborn with negative sex chromatin and the normal external female genitalia. The hyperplastic adrenocortical tissues were generally composed of spongy cells with tremendous accumulation of birefringent crystaline materials. Small lesions containing large crystaline clefts occasionally surrounded by a granulomatous cell-infiltration were additional findings. The adrenal findings were different from those of usual congenital adrenal hyperplasia but similar to those of the case with male pseudohermaphroditism reported by Gurtner (1955). Multifocal adenomatous hyperplasia of the basophils was evident in the anterior pituitary.View full abstractDownload PDF (5333K) -
KINYA OKANO, KEISHI MATSUMOTO, AKIYUKI AKEHI, SHUTARO MIZUTANI, HIDEO ...1963 Volume 10 Issue 4 Pages 221-233
Published: 1963
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSStudies were made on the urinary estrogens and 17-ketosteroids in bilateral gynecomastia. Twenty one cases of gynecomastia were classified into 3 types by estrogen excretion patterns. The daily excretion of estrogen was less than 11.4μg (normal upper limit) in type A (9 cases) and over 11.4μg in type B (9 cases); a partial blocking was observed in the conversion of estradiol-17β and estrone to estriol and 16-epiestriol in type C (3 cases).
In 10 out of 17 cases of gynecomastia, the ratio of etiocholanolone plus androsterone to 11-oxygenated 17-ketosteroids was less than 3. A normal value of the ratio varied from 3 to 10. The ratio of etiocholanolone to androsterone was more than 3 in 2 cases. A normal value ranged from 0.5 to 2. A total amount of 17-ketosteroids was less than a normal range in half the cases of gynecomastia studied.
Thus, in some cases of gynecomastia, it is suggested that breast stimulation is brought about by an increased secretion and/or a decreased rate of inactivation of estrogens, and a decreased secretion of gonadal androgens and/or dehydroepiandrosterone may enhance the action of estrogens on mammary tissues.View full abstractDownload PDF (754K) -
TSUNEHARU SATO, SEIICHI MATSUMOTO1963 Volume 10 Issue 4 Pages 234-242
Published: 1963
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSThe effects of experimentaly induced hypo-and hyperthyroidism on the ovarian response to pregnant mares' serum, or chorionic gonadotrophin were determined in immature rats by administering thiouracil for 7 to 14 days and desiccated thyroid solution for 7 days. A constant dose of PMS or HCG was injected into each animal. It was found that administration of thiouracil or thyroidectomy significantly increased the action of the pregnant mares' serum on the ovaries. However, this effect was not observed in hypophysectomized rats, the same was not observed on the action of HCG. When desiccated thyroid solution was administered to rats, there were significant decreases in ovarian response to PMS. The same results were also obtained in hypophysectomized rats. Furthermore, action of estrogen on the uterus was altered by the amount of thyroxine administered.View full abstractDownload PDF (3447K) -
HIROKO HASEGAWA, MICHIO UI1963 Volume 10 Issue 4 Pages 243-253
Published: 1963
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESS1. In vitro effect of serotonin on hepatic glycogenolysis was observed. Serotonin creatinine sulfate as low as 50μg per ml significantly decreased glycogen content in rat liver slices.
2. Additional dose of serotonin to the medium containing 50μg of epinephrine caused a further stimulation on glycogen breakdown. Therefore serotonin would act in a different manner from epinephrine.
3. The mechanism was discussed for serotonin-induced glycogenolysis which was somewhat similar to that elicited by DBI (phenethylbiguanide).View full abstractDownload PDF (927K) -
TOMOKO FUJII, TERUKO KAMEI, SACHIKO NEGAMI, EMIKO FUJII1963 Volume 10 Issue 4 Pages 254-259
Published: 1963
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSEffect of long-term administration of testosterone propionate (TP) on the function of liver was studied using the Wistar-King A strain rats with special references to the sex and age.
1. RNA and nitrogen contents in the liver mitochondrial fraction of female rats exceeded that in male animals after 40 days of age at which sex maturation began. TP administration produced an increase in the RNA and nitrogen contents in both sexes, particularly in female rats by long-term TP administration.
2. Succinic dehydrogenase activity in the mitochondrial fraction of the liver showed marked sex difference after 40 days of age. The activity in female animals was higher than in males. TP increased the activity of succinic dehydrogenase in male rats, whereas decreased in female rats.
3. Fatty acid dehydrogenase activity showed a marked increase after 40 days of age, but no sex difference appeared. No effects was observed after TP treatment in both sexes.View full abstractDownload PDF (512K) -
SEIICHIRO TARUI, KYOHEI NONAKA1963 Volume 10 Issue 4 Pages 260-262
Published: 1963
Released on J-STAGE: January 25, 2011
JOURNAL FREE ACCESSDownload PDF (215K)
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