A procedure of percutaneous renal biopsy in the prone position has been performed mainly following the Kark and Muehrcke's procedure with minimal modifications. This report was based on a study of first 133 instances of attempted percutaneous needle biopsy of kidney in 88 patients with various renal diseases. Fundamental problems on the clinical application of renal biopsy ; technique, diagnostic evaluations, influence on renal function, side effects and complications, indication or contraindication for this procedure, were investigated and methodology was discussed.

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