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MAKOTO SUNAMORI, JUN AMANO, TAKAAKI KAMEDA, TAKAO OKAMURA, MASAYOSHI O ...
1980 Volume 44 Issue 10 Pages
771-775
Published: November 20, 1980
Released on J-STAGE: April 14, 2008
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Protective action of aprotinin from ischemic myocardial damage was evaluated in 9 patients compared to non-treated 18 patients, who underwent open heart surgery (22 ACB, 3 AVR and 2 MVR) with respect to the alterations of beta-glucronidase, acid-phosphatase, MB-CPK and m-GOT. Cold cardioplegia with glucose-insulin-potassium solution was used in this investigation. Average arrest time was 78.6±4.9 minutes associated with hypothermia between 25 and 280°C in rectal temperature. Aprotinin was administered in 9 patients intravenously with 5, 000 KIU/Kg 30 minutes prior to CPB and then 5, 000 KIU/Kg in the prime solution. Activity of beta-glucronidase was significantly suppressed in the aprotinin-treated group compared to the nontreated group following cardioplegia and in the reperfusion period up to 6 hours, however, acid-phosphatase failed to demonstrate significant difference among two groups. Serum MB-CPK and m-GOT levels in the aprotinin-treated group did not elevate the beginning of reperfusion following cardioplegia. These data suggest that aprotinin add myocardial protection to cold cardioplegia .
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FUJIO NUMANO, HIDENORI MAEZAWA, SUSUMU SAWADA, N TALAL, A.N THEOFILOPO ...
1980 Volume 44 Issue 10 Pages
777-782
Published: November 20, 1980
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Circulating immune complexes in Takayasu disease were investigated to assess the involvement of autoimmune mechanisms. Antibody dependent cellmediated cytotoxicity (ADCC) and Raji cell assay revealed: The 10 percent inhibition of ADCC in 37 patients was 35.6±5 .2, this being a non-statistically significant value as compared with the value of 25.6±3.0 in 33 apparently healthy controls. Raji cell assay values were 30.4±11.5 and 3.5±2.3 for patients and controls, respectively. As 54% of all these patients had a negative reaction and there was no correlation between immune complex levels and BSR, CRP, or ASO, immune complexes, while accelerating or modifying the pathophysiological state, probably are not primary causative factors.
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NOBUSHIGE MIKI, YOHZO FURUSHO, KENICHI ITAYA, KEIICHI MIDORIKAWA, EIIC ...
1980 Volume 44 Issue 10 Pages
783-793
Published: November 20, 1980
Released on J-STAGE: April 14, 2008
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For the purpose of determining exercise intensity required for evaluating the effect of β-blocking agents, the multi-stage treadmill exercise was carried out up to intensity of 85% of maximal oxygen intake (V^^·O
2 max) after administration of β-blocking agents in 7 healthy men. To obtain a stable dose response in the inhibitory effect of β-blocking agents on heart rate (HR) and systolic blood pressure (S-BP), the exercise intensity more than 65% of V^^·O
2 max (75% of maximal heart rate) was needed. In order to evaluate the effect of befunolol (BFE), a submaximal treadmill exercise of 75% of the age adjusted predicted maximal heart rate was loaded in 6 healthy men at 1, 5, 4, and 8 hours following a single oral administration of 10 mg, 20 mg or 40 mg of BFE and 20 mg or 40 mg of propranolol. Simultaneously, the plasma concentration of BFE was determined 1, 5, 4, 6 and 8 hours after the administration of BFE at each dose. In human serum, BFE was detected together with its metabolite, revealing a significant correlation between BFE and metabolite (r = 0.94, p<0.001). Almost a certain rate of metabolite (4-5 times) was detected against BFE. As for the biological half life, it was 1.79±0.13 hours with BFE and 3.67±1.33 hours with metabolite. The inhibitory effect of BFE on HR and S-BP during exercise exhibited a dose response with the oral dose and its plasma concentration, and was almost twice as much as that of propranolol at the same dose. Accordingly, the myocardial oxygen consumption which may be represented as a rate pressure product was inhibited twice as much as propranolol. BFE is characteristic of its more rapid elimination of its effect compared to the other β-blocking agents. The decrease in the inhibitory effect of BFE on HR during exercise was about 1.8 times quicker than that of propranolol.
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YUICHI SHIOKAWA, JUTARO YAMAGATA
1980 Volume 44 Issue 10 Pages
797-800
Published: November 20, 1980
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1. Three cases of rheumatic fever were treated with plasmapheresis. Improvement of abnormal clinical and laboratory findings of the patients was obtained by this procedure. 2. High levels of immune complexes, observed in the sera of patients with rheumatic fever, reduced markedly following plasmapheresis.
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TOSHIHIKO YAMADA, NOZOMU KOSAKAI
1980 Volume 44 Issue 10 Pages
801-803
Published: November 20, 1980
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SEIICHI KAWAKITA, JUNZO INOUE, TSUNE TAKEUCHI, YOSHIO UMEHARA, TOYOHIK ...
1980 Volume 44 Issue 10 Pages
804-807
Published: November 20, 1980
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The throat cultures were collected on swabs from total number of 3, 599 of first grade children of elementary schools in Otsu City in 1978. Beta-hemolytic streptococci were isolated from 628 of 3, 599 children (17.4%). Group A strains were found in 403 of 628 children (64.2%). Thus the frequency of recovery of group A streptococci from the children was 11.2% in this study. The size of tonsils in children with positive cultures for group A streptococci and negative response of ASO was larger than tonsils of children with negative cultures for group A strains and negative ASO response, and were smaller than the tonsils of children with positive cultures for group A strains and with positive ASO response. On the 20th day after oral administration of 400, 000 units of penicillin derivative, group A strains were eradicated from throats in 76.2% of the treated children.
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NOBUO WATANABE, AKIRA ARIMURA, MUNEMITSU KOBAYASHI, MASAHIRO OSHIMA
1980 Volume 44 Issue 10 Pages
808-809
Published: November 20, 1980
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SATOSHI FUJIKUWA, MASAHIKO OKUNI
1980 Volume 44 Issue 10 Pages
810-811
Published: November 20, 1980
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KIYOSHI HOSHINA, MAMI HOSHINA, SANJI KUSAKAWA
1980 Volume 44 Issue 10 Pages
812-813
Published: November 20, 1980
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YUKIO IZUMI, SUSUMU YONESAKA, AKIRA SAITO
1980 Volume 44 Issue 10 Pages
814-816
Published: November 20, 1980
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TEIICHI ODA, KUNIHIRO HAMAMOTO, HIDENOBU MORINAGA
1980 Volume 44 Issue 10 Pages
817-822
Published: November 20, 1980
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A follow-up study of childhood myocarditis for at least 12 months (12-39 months, average 19.7 months) was made on 26 patients. Regular cardiological examinations (X-ray, ECG, PCG, MCG and UCG) and serum enzyme studies (especially LDH isozyme and CPK isozyme) were done. Clinical and cardilogical normalization was seen in 13 (50.0%), not necessarily with normalized enzyme study. Major residual abnormalities were: CRBBB (3), VPC (3), abnormal Q (1), A-V block I° (1), large IVth sound (1) and chronic nonobstructive cardiomyopathy (HNCM) (1). Mild, transient recurrences were seen in 3 . Enzyme abnormalities, which existed at the first visit in all cases, disappeared only in 12. This suggests that somewhat active inflammatory process may persist for years, even after clinical and cardiological normalization. The patient with HNCM had a heavy familial history of cardiomyopathy. The relationship between myocarditis and cardiomyopathy was discussed. It is necessary to examine every patients with cardiomyopathy from the stand of view of myocarditis.
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SHIGEYUKI ECHIGO, TETSURO KAMIYA, KIYOSHI BABA, TSUYOSHI FUJITA, HISAO ...
1980 Volume 44 Issue 10 Pages
823-826
Published: November 20, 1980
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KEISUKE FUKUDA, RYOZO OKADA
1980 Volume 44 Issue 10 Pages
827-832
Published: November 20, 1980
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SHINJI FUKUTA, SETSUKO IWAMOTO, YOSHIO KIMURA, KATSUTOSHI YAMAKAWA, KA ...
1980 Volume 44 Issue 10 Pages
833-837
Published: November 20, 1980
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The production of myocardial lesions and circulating anti-heart antibodies has been studied in rats injected with homologous heart extracts emulsified with the Freund's complete adjuvant and the DTP vaccine. Six of 7 rats showed lesions of focal myocarditis, while only in one of them circulating anti-heart antibodies were detected. There was no correlation between the presence of circulating anti-heart antibodies and that of myocardial lesions. These findings suggested that the circulating anti-heart antibodies may play little or no role in the pathogenesis of this experimental myocarditis.
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AKIRA MATSUMORI, KAZUNORI KADOTA, HIROFUMI KAMABARA, CHUICHI KAWAI
1980 Volume 44 Issue 10 Pages
838-841
Published: November 20, 1980
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The myocardial uptake of technetium-99m pyrophosphate (
99mTc-PYP) in perimyocarditis induced by coxsackievirus B3 in BALB/c mice was studied on 3rd-90th day after the inoculation.
99mTc-PYP uptake ratio, measured by the ratio of cpm/gm for the heart to cpm/gm for the skull, began to increase five days after virus inoculation and reached a maximum on the seventh day. After the 14th day,
99mTc-PYP ratio began to decrease, however, on the 90th day, a high
99mTc-PYP uptake was shown in mice with severe perimyocardial fibrosis and calcification. The present findings may provide a further basis upon which
99mTc-PYP imaging may be applied to viral perimyocarditis in humans.
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AKIRA MATSUMORI, CHUICHI KAWAI, SHIGEO SAWADA, KIYOHARU YAMAMOTO
1980 Volume 44 Issue 10 Pages
842-847
Published: November 20, 1980
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We described severe perimyocarditis in weanling BALB/C mice inoculated with coxsackievirus B3 (Nancy strain) which was exclusively limited to the right ventricle. Yellowish-white patches were seen on the surface of the right ventricle of the heart on the seventh day through 360th day after inoculation with virus. Following myocardial degeneration and necrosis, marked perimyocardial fibrosis with calcification was observed 90 days after inoculation with virus and persisted through 360th day. Spontaneous pericardial lesions were observed in the right ventricle in a few control mice, but these changes were different in severity and localization from perimyocarditis observed in mice infected with coxsackievirus B3. This animal model may provide an opportunity to study the natural course of perimyocarditis of viral etiology and possible sequel chronic or constrictive pericarditis in humans."
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SUNAO HONDA, HIROSHI SUNAGAWA, YASUHIRO MIZOGUCHI, HIROSHI MATSUMOTO, ...
1980 Volume 44 Issue 10 Pages
848-851
Published: November 20, 1980
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Right and left heart catheterizations and biplane cineangiographies were performed on 115 post-MCLS cases to study the left ventricular performance and compliance, and the following conclusions were obtained : 1) The left ventricular performance of the post-MCLS cases with macroscopic cardiac lesions such as coronary aneurysms and stenosis declined compared with the others. 2) The left ventricular contractility of the post-MCLS cases without macroscopic cardiac lesions were within normal limits. 3) The diastolic compliance of the post-MCLS cases seemed to be decreased, but the value could be regarded as normal for children.
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SANGO ITOH, HIROSHI KOBAYASHI, MASAHIKO OKUNI
1980 Volume 44 Issue 10 Pages
852-854
Published: November 20, 1980
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CHUZO MORI, KATSUTOSHI ABE, TOSHIKAZU NISHIO, MASAKAZU SAITO, TAKESHI ...
1980 Volume 44 Issue 10 Pages
855-858
Published: November 20, 1980
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The left ventricular muscle volume (LVMV) and the distance from the anterior chest wall to the middle of the left ventricle (D) were determined echocardiographically in 476 children as a part of the Shimane Heart Study. Correlation of the summed precordial voltage (SV
1 + RV
5) with LVMV was not good (r = 0.377 in males and -0.095 in females). The precordial voltage (SV
1 + RV
5 ), therefore, was corrected by the square of D to compensate the diminution of electrical potential by distance. Correlation between D
2 (SV
1 + RV
5 ) and LVMV was good in males (r = 0.712) and relatively good in females (r = 0.469). Moreover, the values of D
2 (SV
1 + RV
5) were different between both sexes at the age of 12-16 years. The thickness of subcutaneous fat may be one of the most important factors for these differences in D
2 (SV
1 + RV
5 ) and correlation coefficient.
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MITSUO KITADA, SETSUKO NAKAJIMA, KINICHI UHEDA, KENJI YASUTAKE, TADASH ...
1980 Volume 44 Issue 10 Pages
859-862
Published: November 20, 1980
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The rate for sudden unexpected death among the male school children and high school student was 3 .4 per 100, 000, and among the female was 2.0 per 100, 000. The rate showed the tendency to increase with age among the male, but not in the female . Most of the sudden deathes occurred during day time while they were awake and the death during sleep occurred in 9.2%. The sudden death in the school occurred in 26.5%. Concerning the causes of the death, in 20.5% of the cases it was unknown (even though acute heart failure was the terminal symptoms). In 18.1% basal heart disease was responsible, in 15.7% asthmatic spell and in 10.8% cerebral hemorrhage . It was found that 38.6% of the sudden death cases were as usual in the condition preceding to the onset of the symptom, 18.1% of cases had been complaining of tiredness or overwork and 9.6% had been with symptoms of respiratory infection. The sudden death of handicapped children was occupying 25.3% of the deathes encountered in the present study.
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