JAPANESE CIRCULATION JOURNAL
Online ISSN : 1347-4839
Print ISSN : 0047-1828
ISSN-L : 0047-1828
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Volume 34, Issue 9
Displaying 1-5 of 5 articles from this issue
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  • A Transient Leukopenia during Hemodialysis
    TAKESHI ITO, EIJI MATSUI, TOYOO NIWA, MITSUHIKO SUGIURA, TOJI KOJIMA
    1970 Volume 34 Issue 9 Pages 771-774
    Published: November 20, 1970
    Released on J-STAGE: April 14, 2008
    DOIhttps://doi.org/10.1253/jcj.34.771
    JOURNAL FREE ACCESS
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    An acute and transient leukopenia was found during hemodialysis. Leukocyte count fell rapidly and recovered promptly. This change was limited within first 60 minutes after starting of hemodialysis. The major part of leukopenia was neutrocytepenia. A large number of neutrocytes were found on the cuprophane membrane. The accumuration of neutrocyte on the membrane may be the cause of severe transient leukopenia during hemodialysis.
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  • A Quantum Chemical Study with Special Reference to the Sulfamyl Group of Sulfonylureas
    YOSHIMASA ORITA, AKIO ANDO, YOSHIHIOR TAKAMITSU, SHIGEHARU URAKABE, DA ...
    1970 Volume 34 Issue 9 Pages 775-778
    Published: November 20, 1970
    Released on J-STAGE: April 14, 2008
    DOIhttps://doi.org/10.1253/jcj.34.775
    JOURNAL FREE ACCESS
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    HUCKEL's LCAO-MO Method was applied to the sulfamyl part of sulfonylureas and related compounds. The parameters used were already discussed in the authors' previous report. |K| values of the lowest vacant energy level of sulfonylureas were less than those of DPN. Such characteristic nature of the compounds seems to unrelated to their hypoglycemic activity. Hypoglycemic activity, seems to depend on the structural specificity of the nucleophilic reaction site of oxygen symmetrically and the electrophilic reaction site of the sulfur in the sulfamyl part between banzene and the urea portion. Moreover, a specific electronic environment required for the urea portion of sulfonylureas was pointed out as essential nature. A continuous π-electron bonded structure from benzene to the sulfamyl part and to the urea portion seems to be indispensable in enhancing water permeability of the toad bladder. The quantum chemical significance of R and R' portion was discussed.
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  • Effects of Acute Hypoxia on the Pulmonary Vascular Bed in Man
    SHUNNOSHUKE HANDA
    1970 Volume 34 Issue 9 Pages 779-787
    Published: November 20, 1970
    Released on J-STAGE: April 14, 2008
    DOIhttps://doi.org/10.1253/jcj.34.779
    JOURNAL FREE ACCESS
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    Simultaneous right and trans-septal left heart catheterization were performed in cardio-pulmonary patients to investigate the changes in the pulmonary blood now, volume and pressures during acute hypoxia. Indicator dilution procedure with cardio-blue dye was used and the pulmonary blood volume was estimated from the cardiac index multiplied by the mean transit time from the pulmonary artery to left atrium. The distending pressure was estimated by averaging the mean pulmonary arterial and mean left atrial pressures. The effects of acute hypoxia on the pulmonary vascular bed were discussed, related with the changes in these hemodynamic parameters.
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  • A New Depressor Principle in Liver from Normal Rabbit
    TATSUO KOKUBU, EINOSUKE UEDA, KUNIO HIWADA, YUICHI YAMAMURA
    1970 Volume 34 Issue 9 Pages 789-792
    Published: November 20, 1970
    Released on J-STAGE: April 14, 2008
    DOIhttps://doi.org/10.1253/jcj.34.789
    JOURNAL FREE ACCESS
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    The depressor principle, located only in micro-some fraction of normal rabbit liver cell by the method of SCHNEIDER, was isolated by heat treatment, fractionation of ammonium sulfate between 0-70% saturation of the supernatant, DEAE-Sephadex A-50 column chromatography and zone electrophoresis. Intravenous injection of the principle showed relatively a long sustained depressor effect in comparison with that of bradykinin or adenosine in a normal rabbit and rat. The ultraviolet absorption maximum of the principle was 256mμ. The mean molecular weight was 36, 000 by ARCHIBALD method and about 90% was RNA. Nucleotide analysis showed CMP 20%, UMP 14%, AMP 7% and GMP 59%.
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  • Electron Microscopic Study on Distribution of Sodium and Potassium Ion in Cardiac Ventricle Muscle Cells Influenced by Ouabain
    SHIN-ICHI SHIINA, VINCHI MIZUHIRA
    1970 Volume 34 Issue 9 Pages 793-797
    Published: November 20, 1970
    Released on J-STAGE: April 14, 2008
    DOIhttps://doi.org/10.1253/jcj.34.793
    JOURNAL FREE ACCESS
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    Potassium ion in the cardiac muscle cell was observed histochemically as the precipitate of potassium cobaltinitrite. It was decreased by the administration of the therapeutic dose of ouabain. Sodium ion was observed as the precipitate of sodium antimonate. It was also decreased by ouabain. Since these techniques have not been utilized yet in this field, this paper presents new data on the change of the electrolyte metabolism and discusses about the positive inotropic effect of ouabain.
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