JAPANESE CIRCULATION JOURNAL

SUPRAVALVULAR AORTIC STENOSIS ASSSOCIATED WITHAORTIC ANEURYSM

SHUNNNOSUKE HANDA, HAJIME YAMAZAKI, BERNAWALD SCHOELKENS.H, YOSHIRO NA ...

1971 Volume 35 Issue 3 Pages 323-328
Published: April 20, 1971
Released on J-STAGE: April 14, 2008

DOIhttps://doi.org/10.1253/jcj.35.323

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A 32-year-old female patient had supravalvular aortic stenosis associated with aortic aneurysm. Supravalvular location of aortic stenosis within this rare combination of lesions has not, as far as we are aware, been reported. From the pathological findings, the nozzle action of stenosis is presumed to be an important causative factor in the growth of aneurysm.

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CARDIAC MYOFIBRILLAR ATPase ACTIVITY IN THE SPONTANEOUSLY HYPERTENSIVE RAT

KYUZO AOKI, NOBUKO IKEDA, KEN HOTTA

1971 Volume 35 Issue 3 Pages 329-331
Published: April 20, 1971
Released on J-STAGE: April 14, 2008

DOIhttps://doi.org/10.1253/jcj.35.329

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Myofibrillar ATPase activity was determined in the hearts of the spontaneously hypertensive, renal hypertensive and normotensive rats. There was no significant difference of myofibrillar ATPase activity per unit protein between the hypertensive and normotensive hearts. However, increases of myofibrillar ATPase activity per heart were found in both the spontaneously and renal hypertensive rats as was to be expected, because the ratio of heart to body weight was significantly increased. Therefore, external cardiac work might be increased in hypertensive hypertrophied heart.

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NATURE OF LYSOSOMAL ANGIOTENSINASE ACTIVITY

MASAO MATSUNAGA

1971 Volume 35 Issue 3 Pages 333-338
Published: April 20, 1971
Released on J-STAGE: April 14, 2008

DOIhttps://doi.org/10.1253/jcj.35.333

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Acid angiotensinase activity is present in lysosomes of rat kidney and liver. The nature of this activity was investigated by bioassay and paper chromatography, using various angiotensin analogues as substrates. The main part of the lysosomal angiotensinase activity, especially on [Ile⁵]-angiotensin II, is due to a carboxypeptidase which releases C-terminal phenylalanine. This enzyme is independent of sulthydryl groups and is inhibited by DFP. It is differentiated from cathepsin A or catheptic carboxypeptidase by its heat stability. The remaining part of the angiotensinase activity is sulthydryl-dependent and not inhibited by DFP. This is attributed to a chymotrypsin-like or a trypsin-like action or both. Rat plasma after dialysis against EDTA had a slight acid angiotensinase activity and released phenylalanine.

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THE CLINICAL TRIAL OF A NEW HYPOTENSIVE AGENT, "FUSARIC ACID (5-BUTYLPICOLINIC ACID)": THE PRELIMINARY REPORT

FUJIO TERASAWA, MASAKUNI KAMEYAMA

1971 Volume 35 Issue 3 Pages 339-357
Published: April 20, 1971
Released on J-STAGE: April 14, 2008

DOIhttps://doi.org/10.1253/jcj.35.339

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Fusaric acid (5-butylpicolinic acid) was found to be a potent inhibitor of dopamine β-hydroxylase in vitro and in vivo. The depression of the levels of endogenous norepinephrine was demonstrated in brain, heart, spleen and adrenal glands of the rat. This compound showed a consistent hypotensive effect in experimental animals, also. This study was conducted to prove the hypotensive activity of this compound in humans, for the purpose of testing whether or not this compound could be a unique antihypertensive drug in clinical medicine.

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