Being encouraged by the statistical results of the previous report on U wave changes in patients with neurogenic cardiac complaints, the author investigated the similarity and difference in ECG between actual neurosis (Aktualneurose) and hyperthyroidism. It seemed to the author that there may be a borderline case between actual neurosis and hyperthyroidism as there is a borderline hypertension between normotension and hypertension, and that an analysis of clinical records might add something to our knowledge of the causation of the U wave.

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Primary tumor of the heart is comparatively rare. Recently, as the results of development of the cardiac catheterization, cardiovascular angiography and artificial heart-lung, both pre-operative diagnosis and successful extirpation of the tumor seem to be made more frequently. The case reported by SAKAKIBARA (1960) seems to be first one which operation succeeded in Japan. Concerning the nature of myxoma there are two theories, one is neoplastic, and the other non-neoplastic. And the latter has considered it to be a organized thrombus. With the diagnosis of mitral stenosis, operation was performed on a 28 years female to find a walnut-sized myxoma in the atrium. Because the artificial heart was not ready for use, the operation was terminated as exploratory one.

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While a number of methods to study the metabolism of the kidney have been advanced and used, including indirect methods and those based on the analogy from the results of animal experiments, the recent development of the renal venous catheterization method made possible the direct sampling of the renal venous blood in man and so to study the human renal metabolism under the physiological and pathological conditions. The reports based on the renal catheterization have been accumulated recently both abroad and in this country and these studies shed light upon the renal blood circulation in man, but the study concerning the carbohydrate metabolism of the kidney with special reference to renal circulation and renal oxygen metabolism has been little reported. As an approach to the problem of the carbohydrate metabolism of the kidney, the author studied healty subjects and patients by the renal venous catheterization method in a resting condition (Part I) and during induced hypoxemia by 10% O₂ gas inhalation(Part II). Investigation was made on several problems with special reference to the renal uptake and release of such substances, as glucose, lactic acid and pyruvic acid. Subjects Subjects used, were a total of 20 cases, consisting of the following groups. a. Healthy subjects 7 cases b. Patients with pulmonary tuberculosis 5 cases c. Patients with essential hypertension 5 cases d. Patients with nephrosclerosis 3 cases Methods Under resting condition, arterial blood (obtained directly through a needle attached to shringe that had been inserted into the femoral artery) and renal venous blood (obtained by the renal venous catheterization method) were obtained as simultaneously as possible. After the initial samplings of blood were done, hypoxemia was induced and maintained by the method of Levy with 10% O₂ gas inhalation for 20 minutes ; the blood samples were obtained between 15 and 20 minutes of the hypoxia test. The concentration of glucose was determined by the Somogyi's method, that of lactate by the hydroxybiphenyl method, and that of pyruvate by the dinitrophenylhydrazine method. For the calculation of the renal uptake and release of various substances, the renal blood blow (T. R.B.F.), as reported by FUKUDA, the author's collaborator, was used.

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